Nonsense-mediated mRNA decay factor SMG8 (Amplified in breast cancer gene 2 protein) (Protein smg-8 homolog)
1_MAGPV 6_ SLRDL 11_ LMGAS 16_ AWMGS 21_ ESPGG 26_ SPTEG 31_ GGSAA 36_ GGPEP 41_ PWRED 46_ EICVV 51_ GIFGK 56_ TALRL 61_ NSEKF 66_ SLVNT 71_ VCDRQ 76_ VFPLF 81_ RHQDP 86_ GDPGP 91_ GIRTE 96_ AGAVG 101_ EAGGA 106_ EDPGA 111_ AAGGS 116_ VRGSG 121_ AVAEG 126_ NRTEA 131_ GSQDY 136_ SLLQA 141_ YYSQE 146_ SKVLY 151_ LLLTS 156_ ICDNS 161_ QLLRA 166_ CRALQ 171_ SGEAG 176_ GGLSL 181_ PHAEA 186_ HEFWK 191_ HQEKL 196_ QCLSL 201_ LYLFS 206_ VCHIL 211_ LLVHP 216_ TCSFD 221_ ITYDR 226_ VFRAL 231_ DGLRQ 236_ KVLPL 241_ LKTAI 246_ KDCPV 251_ GKDWK 256_ LNCRP 261_ CPPRL 266_ LFLFQ 271_ LNGAL 276_ KVEPP 281_ RNQDP 286_ AHPDK 291_ PKKHS 296_ PKRRL 301_ QHALE 306_ DQIYR 311_ IFRKS 316_ RVLTN 321_ QSINC 326_ LFTVP 331_ ANQAF 336_ VYIVP 341_ GSQEE 346_ DPVGM 351_ LLDQL 356_ RSHCT 361_ VKDPE 366_ SLLVP 371_ APLSG 376_ PRRYQ 381_ VMRQH 386_ SRQQL 391_ SFHID 396_ SSSSS 401_ SSGQL 406_ VDFTL 411_ REFLW 416_ QHVEL 421_ VLSKK 426_ GFDDS 431_ VGRNP 436_ QPSHF 441_ ELPTY 446_ QKWIS 451_ AASKL 456_ YEVAI 461_ DGKEE 466_ DLGSP 471_ TGELT 476_ SKILS 481_ SIKVL 486_ EGFLD 491_ IDTKF 496_ SENRC 501_ QKALP 506_ MAHSA 511_ YQSNL 516_ PHNYT 521_ MTVHK 526_ NQLAQ 531_ ALRVY 536_ SQHAR 541_ GPAFH 546_ KYAMQ 551_ LHEDC 556_ YKFWS 561_ NGHQL 566_ CEERS 571_ LTDQH 576_ CVHKF 581_ HSLPK 586_ SGEKP 591_ EADRN 596_ PPVLY 601_ HNSRA 606_ RSTGA 611_ CNCGR 616_ KQAPR 621_ DDPFD 626_ IKAAN 631_ YDFYQ 636_ LLEEK 641_ CCGKL 646_ DHINF 651_ PVFEP 656_ STPDP 661_ APAKN 666_ ESSPA 671_ PPDSD 676_ ADKLK 681_ EKEPQ 686_ TQGES 691_ TSLSL 696_ ALSLG 701_ QSTDS 706_ LGTYP 711_ ADPQA 716_ GGDNP 721_ EVHGQ 726_ VEVKT 731_ EKRPN 736_ FVDRQ 741_ ASTVE 746_ YLPGM 751_ LHSNC 756_ PKGLL 761_ PKFSS 766_ WSLVK 771_ LGPAK 776_ SYNFH 781_ TGLDQ 786_ QGFIP 791_ GTNYL 796_ MPWDI 801_ VIRTR 806_ AEDEG 811_ DLDTN 816_ SWPAP 821_ NKAIP 826_ GKRSA 831_ VVMGR 836_ GRRRD 841_ DIARA 846_ FVGFE 851_ YEDSR 856_ GRRFM 861_ CSGPD 866_ KVMKV 871_ MGSGP 876_ KESAL 881_ KALNS 886_ DMPLY 891_ ILSSS 896_ QGRGL 901_ KPHYA 906_ QLMRL 911_ FVVVP 916_ DAPLQ 921_ IILMP 926_ QVQPG 931_ PPPCP 936_ VFYPE 941_ KQEIT 946_ LPPDG 951_ LWVLR 956_ FPYAY 961_ VTERG 966_ PCFPP 971_ KENVQ 976_ LMSYK 981_ VLRGV 986_LKAVT
1: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity