E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (Nerve injury-induced gene 283 protein) (RING-type E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)
1_MGGKQ 6_ STAAR 11_ SRGPF 16_ PGVST 21_ DDSAV 26_ PPPGG 31_ APHFG 36_ HYRTG 41_ GGAMG 46_ LRSRS 51_ VSSVA 56_ GMGMD 61_ PSTAG 66_ GVPFG 71_ LYTPA 76_ SRGTG 81_ DSERA 86_ PGGGG 91_ SASDS 96_ TYAHG 101_ NGYQE 106_ TGGGH 111_ HRDGM 116_ LYLGS 121_ RASLA 126_ DALPL 131_ HIAPR 136_ WFSSH 141_ SGFKC 146_ PICSK 151_ SVASD 156_ EMEMH 161_ FIMCL 166_ SKPRL 171_ SYNDD 176_ VLTKD 181_ AGECV 186_ ICLEE 191_ LLQGD 196_ TIARL 201_ PCLCI 206_ YHKSC 211_ IDSWF 216_ EVNRS 221_CPEHP
1: E3 ubiquitin-protein ligase that plays a role in different processes including cell differentiation, receptor recycling or regulation of inflammation (PubMed:28593998, PubMed:33996800, PubMed:37158982). Mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons. Ubiquitinates the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1 and thereby influences its endocytosis and/or degradation (PubMed:22797923). Controls ligand-induced EGFR signaling via mediating receptor ubiquitination and recruitment of the ESCRT machinery (PubMed:33996800). Acts as a negative feedback mechanism controlling TLR3 trafficking by mediating TLR3 'Lys-63'-linked polyubiquitination to reduce type I IFN production (PubMed:37158982). Modulates inflammation by promoting caveolin-1/CAV1 ubiquitination and degradation to regulate TLR4-activated immune response (PubMed:28593998)