Terminal nucleotidyltransferase 4B (Non-canonical poly(A) RNA polymerase PAPD5) (EC 2.7.7.19) (PAP-associated domain-containing protein 5) (Terminal guanylyltransferase) (EC 2.7.7.-) (Terminal uridylyltransferase 3) (TUTase 3) (Topoisomerase-related function protein 4-2) (TRF4-2)
1_MYRSG 6_ ERLLG 11_ SHALP 16_ AEQRD 21_ FLPLE 26_ TTNNN 31_ NNHHQ 36_ PGAWA 41_ RRAGS 46_ SASSP 51_ PSASS 56_ SPHPS 61_ AAVPA 66_ ADPAD 71_ SASGS 76_ SNKRK 81_ RDNKA 86_ SGGRA 91_ AGGGR 96_ ADGGG 101_ VVYSG 106_ TPWKR 111_ RNYNQ 116_ GVVGL 121_ HEEIS 126_ DFYEY 131_ MSPRP 136_ EEEKM 141_ RMEVV 146_ NRIES 151_ VIKEL 156_ WPSAD 161_ VQIFG 166_ SFKTG 171_ LYLPT 176_ SDIDL 181_ VVFGK 186_ WENLP 191_ LWTLE 196_ EALRK 201_ HKVAD 206_ EDSVK 211_ VLDKA 216_ TVPII 221_ KLTDS 226_ FTEVK 231_ VDISF 236_ NVQNG 241_ VRAAD 246_ LIKDF 251_ TKKYP 256_ VLPYL 261_ VLVLK 266_ QFLLQ 271_ RDLNE 276_ VFTGG 281_ IGSYS 286_ LFLMA 291_ VSFLQ 296_ LHPRE 301_ DACIP 306_ NTNYG 311_ VLLIE 316_ FFELY 321_ GRHFN 326_ YLKTG 331_ IRIKD 336_ GGSYV 341_ AKDEV 346_ QKNML 351_ DGYRP 356_ SMLYI 361_ EDPLQ 366_ PGNDV 371_ GRSSY 376_ GAMQV 381_ KQAFD 386_ YAYVV 391_ LSHAV 396_ SPIAK 401_ YYPNN 406_ ETESI 411_ LGRII 416_ RVTDE 421_ VATYR 426_ DWISK 431_ QWGLK 436_ NRPEP 441_ SCNGP 446_ VSSSS 451_ ATQSS 456_ SSDVD 461_ SDATP 466_ CKTPK 471_ QLLCR 476_ PSTGN 481_ RVGSQ 486_ DVSLE 491_ SSQAV 496_ GKMQS 501_ TQTTN 506_ TSNST 511_ NKSQH 516_ GSARL 521_ FRSSS 526_ KGFQG 531_ TTQTS 536_ HGSLM 541_ TNKQH 546_ QGKSN 551_ NQYYH 556_ GKKRK 561_ HKRDA 566_PLSDL
1: Terminal nucleotidyltransferase that catalyzes preferentially the transfer of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation (PubMed:21788334, PubMed:30026317). Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro) (PubMed:21788334, PubMed:21855801). Required for cytoplasmic polyadenylation of mRNAs involved in carbohydrate metabolism, including the glucose transporter SLC2A1/GLUT1 (PubMed:28383716). Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion (PubMed:18172165). Mediates 3' adenylation of the microRNA MIR21 followed by its 3'-to-5' trimming by the exoribonuclease PARN leading to degradation (PubMed:25049417). Mediates 3' adenylation of H/ACA box snoRNAs (small nucleolar RNAs) followed by its 3'-to-5' trimming by the exoribonuclease PARN which enhances snoRNA stability and maturation (PubMed:22442037)