Cytosolic carboxypeptidase-like protein 5 (EC 3.4.17.-) (EC 3.4.17.24) (ATP/GTP-binding protein-like 5) (Protein deglutamylase CCP5)
1_MELRC 6_ GGLLF 11_ SSRFD 16_ SGNLA 21_ HVEKV 26_ ESLSS 31_ DGEGV 36_ GGGAS 41_ ALTSG 46_ IASSP 51_ DYEFN 56_ VWTRP 61_ DCAET 66_ EFENG 71_ NRSWF 76_ YFSVR 81_ GGMPG 86_ KLIKI 91_ NIMNM 96_ NKQSK 101_ LYSQG 106_ MAPFV 111_ RTLPT 116_ RPRWE 121_ RIRDR 126_ PTFEM 131_ TETQF 136_ VLSFV 141_ HRFVE 146_ GRGAT 151_ TFFAF 156_ CYPFS 161_ YSDCQ 166_ ELLNQ 171_ LDQRF 176_ PENHP 181_ THSSP 186_ LDTIY 191_ YHREL 196_ LCYSL 201_ DGLRV 206_ DLLTI 211_ TSCHG 216_ LREDR 221_ EPRLE 226_ QLFPD 231_ TSTPR 236_ PFRFA 241_ GKRIF 246_ FLSSR 251_ VHPGE 256_ TPSSF 261_ VFNGF 266_ LDFIL 271_ RPDDP 276_ RAQTL 281_ RRLFV 286_ FKLIP 291_ MLNPD 296_ GVVRG 301_ HYRTD 306_ SRGVN 311_ LNRQY 316_ LKPDA 321_ VLHPA 326_ IYGAK 331_ AVLLY 336_ HHVHS 341_ RLNSQ 346_ SSSEH 351_ QPSSC 356_ LPPDA 361_ PVSDL 366_ EKANN 371_ LQNEA 376_ QCGHS 381_ ADRHN 386_ AEAWK 391_ QTEPA 396_ EQKLN 401_ SVWIM 406_ PQQSA 411_ GLEES 416_ APDTI 421_ PPKES 426_ GVAYY 431_ VDLHG 436_ HASKR 441_ GCFMY 446_ GNSFS 451_ DESTQ 456_ VENML 461_ YPKLI 466_ SLNSA 471_ HFDFQ 476_ GCNFS 481_ EKNMY 486_ ARDRR 491_ DGQSK 496_ EGSGR 501_ VAIYK 506_ ASGII 511_ HSYTL 516_ ECNYN 521_ TGRSV 526_ NSIPA 531_ ACHDN 536_ GRASP 541_ PPPPA 546_ FPSRY 551_ TVELF 556_ EQVGR 561_ AMAIA 566_ ALDMA 571_ ECNPW 576_ PRIVL 581_ SEHSS 586_ LTNLR 591_ AWMLK 596_ HVRNS 601_ RGLSS 606_ TLNVG 611_ VNKKR 616_ GLRTP 621_ PKSHN 626_ GLPVS 631_ CSENT 636_ LSRAR 641_ SFSTG 646_ TSAGG 651_ SSSSQ 656_ QNSPQ 661_ MKNSP 666_ SFPFH 671_ GSRPA 676_ GLPGL 681_ GSSTQ 686_ KVTHR 691_ VLGPV 696_ REPRS 701_ QDRRR 706_ QQQPL 711_ NHRPA 716_ GSLAP 721_ SPAPT 726_ SSGPA 731_ SSHKL 736_ GSCLL 741_ PDSFN 746_ IPGSS 751_ CSLLS 756_ SGDKP 761_ EAVMV 766_ IGKGL 771_ LGTGA 776_ RMPCI 781_ KTRLQ 786_ ARPRL 791_ GRGSP 796_ PTRRG 801_ MKGSS 806_ GPTSP 811_ TPRTR 816_ ESSEL 821_ ELGSC 826_ SATPG 831_ LPQAR 836_ PPRPR 841_ SAPAF 846_ SPISC 851_ SLSDS 856_ PSWNC 861_ YSRGP 866_ LGQPE 871_ VCFVP 876_ KSPPL 881_TVSPR
1: Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Cleaves alpha- and gamma-linked polyglutamate tubulin side-chain, as well as the branching point glutamate. Also catalyzes the removal of alpha-linked glutamate residues from the carboxy-terminus of alpha-tubulin. Mediates deglutamylation of nucleotidyltransferase CGAS, leading to CGAS antiviral defense response activation