Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 (EC 2.4.99.7) (GalNAc alpha-2,6-sialyltransferase III) (ST6GalNAc III) (ST6GalNAcIII) (STY) (Sialyltransferase 7C) (SIAT7-C)
1_MACIL 6_ KRKSV 11_ IAVSF 16_ IAAFL 21_ FLLVV 26_ RLVNE 31_ VNFPL 36_ LLNCF 41_ GQPGT 46_ KWIPF 51_ SYTYR 56_ RPLRT 61_ HYGYI 66_ NVKTQ 71_ EPLQL 76_ DCDLC 81_ AIVSN 86_ SGQMV 91_ GQKVG 96_ NEIDR 101_ SSCIW 106_ RMNNA 111_ PTKGY 116_ EEDVG 121_ RMTMI 126_ RVVSH 131_ TSVPL 136_ LLKNP 141_ DYFFK 146_ EANTT 151_ IYVIW 156_ GPFRN 161_ MRKDG 166_ NGIVY 171_ NMLKK 176_ TVGIY 181_ PNAQI 186_ YVTTE 191_ KRMSY 196_ CDGVF 201_ KKETG 206_ KDRVQ 211_ SGSYL 216_ STGWF 221_ TFLLA 226_ MDACY 231_ GIHVY 236_ GMIND 241_ TYCKT 246_ EGYRK 251_ VPYHY 256_ YEQGR 261_ DECDE 266_ YFLHE 271_ HAPYG 276_ GHRFI 281_ TEKKV 286_ FAKWA 291_ KKHRI 296_IFTHP
1: Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of glycoproteins and glycolipids forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto a GalNAc residue inside the backbone core chains. ST6GalNAcIII prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b (PubMed:16169874, PubMed:17123352). GD1alpha is a critical molecule in the communication and interaction between neuronal cells and their supportive cells, particularly in brain tissues, and functions as an adhesion molecule in the process of metastasis (By similarity). Sialylation of glycoproteins or glycosphingolipids is very important in tumor development, neuronal development, nerve repair, immunological processes and regulation of hormone sensitivity (PubMed:17123352)