Vesicular glutamate transporter 3 (VGluT3) (Solute carrier family 17 member 8)
1_MPFKA 6_ FDTFK 11_ EKILK 16_ PGKEG 21_ VKNAV 26_ GDSLG 31_ ILQRK 36_ IDGTT 41_ EEEDN 46_ IELNE 51_ EGRPV 56_ QTSRP 61_ SPPLC 66_ DCHCC 71_ GLPKR 76_ YIIAI 81_ MSGLG 86_ FCISF 91_ GIRCN 96_ LGVAI 101_ VEMVN 106_ NSTVY 111_ VDGKP 116_ EIQTA 121_ QFNWD 126_ PETVG 131_ LIHGS 136_ FFWGY 141_ IMTQI 146_ PGGFI 151_ SNKFA 156_ ANRVF 161_ GAAIF 166_ LTSTL 171_ NMFIP 176_ SAARV 181_ HYGCV 186_ MCVRI 191_ LQGLV 196_ EGVTY 201_ PACHG 206_ MWSKW 211_ APPLE 216_ RSRLA 221_ TTSFC 226_ GSYAG 231_ AVVAM 236_ PLAGV 241_ LVQYI 246_ GWSSV 251_ FYIYG 256_ MFGII 261_ WYMFW 266_ LLQAY 271_ ECPAA 276_ HPTIS 281_ NEEKT 286_ YIETS 291_ IGEGA 296_ NVVSL 301_ SKFST 306_ PWKRF 311_ FTSLP 316_ VYAII 321_ VANFC 326_ RSWTF 331_ YLLLI 336_ SQPAY 341_ FEEVF 346_ GFAIS 351_ KVGLL 356_ SAVPH 361_ MVMTI 366_ VVPIG 371_ GQLAD 376_ YLRSR 381_ QILTT 386_ TAVRK 391_ IMNCG 396_ GFGME 401_ ATLLL 406_ VVGFS 411_ HTKGV 416_ AISFL 421_ VLAVG 426_ FSGFA 431_ ISGFN 436_ VNHLD 441_ IAPRY 446_ ASILM 451_ GISNG 456_ VGTLS 461_ GMVCP 466_ LIVGA 471_ MTRHK 476_ TREEW 481_ QNVFL 486_ IAALV 491_ HYSGV 496_ IFYGV 501_ FASGE 506_ KQEWA 511_ DPENL 516_ SEEKC 521_ GIIDQ 526_ DELAE 531_ EIELN 536_ HESFA 541_ SPKKK 546_ MSYGA 551_ TSQNC 556_ EVQKK 561_ EWKGQ 566_ RGATL 571_ DEEEL 576_ TSYQN 581_EERNF
1: Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, sodium and phosphate (PubMed:12151341, PubMed:33440152). At the synaptic vesicle membrane, mainly functions as an uniporter that mediates the uptake of L-glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells (PubMed:12151341). The L-glutamate uniporter activity is electrogenic and is driven by the proton electrochemical gradient, mainly by the electrical gradient established by the vacuolar H(+)-ATPase across the synaptic vesicle membrane (PubMed:12151341). In addition, functions as a chloride channel that allows a chloride permeation through the synaptic vesicle membrane that affects the proton electrochemical gradient and promotes synaptic vesicles acidification (By similarity). At the plasma membrane, following exocytosis, functions as a symporter of Na(+) and phosphate from the extracellular space to the cytoplasm allowing synaptic phosphate homeostasis regulation (Probable). The symporter activity is electrogenic (PubMed:33440152). Moreover, operates synergistically with SLC18A3/VACHT under a constant H(+) gradient, thereby allowing striatal vesicular acetylcholine uptake (By similarity)