Calcium uniporter protein, mitochondrial (HsMCU) (Coiled-coil domain-containing protein 109A)
1_MAAAA 6_ GRSLL 11_ LLLSS 16_ RGGGG 21_ GGAGG 26_ CGALT 31_ AGCFP 36_ GLGVS 41_ RHRQQ 46_ QHHRT 51_ VHQRI 56_ ASWQN 61_ LGAVY 66_ CSTVV 71_ PSDDV 76_ TVVYQ 81_ NGLPV 86_ ISVRL 91_ PSRRE 96_ RCQFT 101_ LKPIS 106_ DSVGV 111_ FLRQL 116_ QEEDR 121_ GIDRV 126_ AIYSP 131_ DGVRV 136_ AASTG 141_ IDLLL 146_ LDDFK 151_ LVIND 156_ LTYHV 161_ RPPKR 166_ DLLSH 171_ ENAAT 176_ LNDVK 181_ TLVQQ 186_ LYTTL 191_ CIEQH 196_ QLNKE 201_ RELIE 206_ RLEDL 211_ KEQLA 216_ PLEKV 221_ RIEIS 226_ RKAEK 231_ RTTLV 236_ LWGGL 241_ AYMAT 246_ QFGIL 251_ ARLTW 256_ WEYSW 261_ DIMEP 266_ VTYFI 271_ TYGSA 276_ MAMYA 281_ YFVMT 286_ RQEYV 291_ YPEAR 296_ DRQYL 301_ LFFHK 306_ GAKKS 311_ RFDLE 316_ KYNQL 321_ KDAIA 326_ QAEMD 331_ LKRLR 336_ DPLQV 341_ HLPLR 346_QIGEK
1: Channel-forming and calcium-conducting subunit of the mitochondrial inner membrane calcium uniporter complex (uniplex), which mediates calcium uptake into the mitochondrial matrix (PubMed:21685886, PubMed:21685888, PubMed:22822213, PubMed:22829870, PubMed:22904319, PubMed:23101630, PubMed:23178883, PubMed:23755363, PubMed:24332854, PubMed:24560927, PubMed:26341627, PubMed:29954988, PubMed:29995857, PubMed:30454562, PubMed:30638448, PubMed:31080062, PubMed:32494073, PubMed:32762847, PubMed:33296646, PubMed:37036971, PubMed:37126688). MCU channel activity is regulated by the calcium-sensor subunits of the uniplex MICU1 and MICU2 (or MICU3) (PubMed:24560927, PubMed:26903221, PubMed:30454562, PubMed:30638448, PubMed:32494073, PubMed:32762847, PubMed:37036971, PubMed:37126688). Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates ATP production, cytoplasmic calcium signals and activation of cell death pathways (PubMed:21685886, PubMed:21685888, PubMed:22822213, PubMed:22829870, PubMed:22904319, PubMed:23101630, PubMed:23178883, PubMed:23755363, PubMed:24332854, PubMed:24560927, PubMed:26341627, PubMed:29954988, PubMed:32494073, PubMed:32762847). Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes (PubMed:22822213). While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a 'fight-or-flight' response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells (PubMed:25603276). Participates in mitochondrial permeability transition during ischemia-reperfusion injury (By similarity). Mitochondrial calcium uptake in skeletal muscle cells is involved in muscle size in adults (By similarity). Regulates synaptic vesicle endocytosis kinetics in central nerve terminal (By similarity). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22829870, PubMed:22904319). Involved in antigen processing and presentation (By similarity)