Phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3-kinase type 3) (PI3K type 3) (PtdIns-3-kinase type 3) (EC 2.7.1.137) (Phosphatidylinositol 3-kinase p100 subunit) (Phosphoinositide-3-kinase class 3) (hVps34)
1_MGEAE 6_ KFHYI 11_ YSCDL 16_ DINVQ 21_ LKIGS 26_ LEGKR 31_ EQKSY 36_ KAVLE 41_ DPMLK 46_ FSGLY 51_ QETCS 56_ DLYVT 61_ CQVFA 66_ EGKPL 71_ ALPVR 76_ TSYKA 81_ FSTRW 86_ NWNEW 91_ LKLPV 96_ KYPDL 101_ PRNAQ 106_ VALTI 111_ WDVYG 116_ PGKAV 121_ PVGGT 126_ TVSLF 131_ GKYGM 136_ FRQGM 141_ HDLKV 146_ WPNVE 151_ ADGSE 156_ PTKTP 161_ GRTSS 166_ TLSED 171_ QMSRL 176_ AKLTK 181_ AHRQG 186_ HMVKV 191_ DWLDR 196_ LTFRE 201_ IEMIN 206_ ESEKR 211_ SSNFM 216_ YLMVE 221_ FRCVK 226_ CDDKE 231_ YGIVY 236_ YEKDG 241_ DESSP 246_ ILTSF 251_ ELVKV 256_ PDPQM 261_ SMENL 266_ VESKH 271_ HKLAR 276_ SLRSG 281_ PSDHD 286_ LKPNA 291_ ATRDQ 296_ LNIIV 301_ SYPPT 306_ KQLTY 311_ EEQDL 316_ VWKFR 321_ YYLTN 326_ QEKAL 331_ TKFLK 336_ CVNWD 341_ LPQEA 346_ KQALE 351_ LLGKW 356_ KPMDV 361_ EDSLE 366_ LLSSH 371_ YTNPT 376_ VRRYA 381_ VARLR 386_ QADDE 391_ DLLMY 396_ LLQLV 401_ QALKY 406_ ENFDD 411_ IKNGL 416_ EPTKK 421_ DSQSS 426_ VSENV 431_ SNSGI 436_ NSAEI 441_ DSSQI 446_ ITSPL 451_ PSVSS 456_ PPPAS 461_ KTKEV 466_ PDGEN 471_ LEQDL 476_ CTFLI 481_ SRACK 486_ NSTLA 491_ NYLYW 496_ YVIVE 501_ CEDQD 506_ TQQRD 511_ PKTHE 516_ MYLNV 521_ MRRFS 526_ QALLK 531_ GDKSV 536_ RVMRS 541_ LLAAQ 546_ QTFVD 551_ RLVHL 556_ MKAVQ 561_ RESGN 566_ RKKKN 571_ ERLQA 576_ LLGDN 581_ EKMNL 586_ SDVEL 591_ IPLPL 596_ EPQVK 601_ IRGII 606_ PETAT 611_ LFKSA 616_ LMPAQ 621_ LFFKT 626_ EDGGK 631_ YPVIF 636_ KHGDD 641_ LRQDQ 646_ LILQI 651_ ISLMD 656_ KLLRK 661_ ENLDL 666_ KLTPY 671_ KVLAT 676_ STKHG 681_ FMQFI 686_ QSVPV 691_ AEVLD 696_ TEGSI 701_ QNFFR 706_ KYAPS 711_ ENGPN 716_ GISAE 721_ VMDTY 726_ VKSCA 731_ GYCVI 736_ TYILG 741_ VGDRH 746_ LDNLL 751_ LTKTG 756_ KLFHI 761_ DFGYI 766_ LGRDP 771_ KPLPP 776_ PMKLN 781_ KEMVE 786_ GMGGT 791_ QSEQY 796_ QEFRK 801_ QCYTA 806_ FLHLR 811_ RYSNL 816_ ILNLF 821_ SLMVD 826_ ANIPD 831_ IALEP 836_ DKTVK 841_ KVQDK 846_ FRLDL 851_ SDEEA 856_ VHYMQ 861_ SLIDE 866_ SVHAL 871_ FAAVV 876_ EQIHK 881_FAQYW
1: Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (PubMed:14617358, PubMed:33637724, PubMed:7628435). As part of PI3KC3-C1, promotes endoplasmic reticulum membrane curvature formation prior to vesicle budding (PubMed:32690950). Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20208530, PubMed:20643123). Involved in the transport of lysosomal enzyme precursors to lysosomes (By similarity). Required for transport from early to late endosomes (By similarity)
2: (Microbial infection) Kinase activity is required for SARS coronavirus-2/SARS-CoV-2 replication