Gene name: MNS1

Uniprot entry:

Q8NEH6

Protein names:

Meiosis-specific nuclear structural protein 1

Protein sequence:

1_MGSKR 6_ RNLSC 11_ SERHQ 16_ KLVDE 21_ NYCKK 26_ LHVQA 31_ LKNVN 36_ SQIRN 41_ QMVQN 46_ ENDNR 51_ VQRKQ 56_ FLRLL 61_ QNEQF 66_ ELDME 71_ EAIQK 76_ AEENK 81_ RLKEL 86_ QLKQE 91_ EKLAM 96_ ELAKL 101_ KHESL 106_ KDEKM 111_ RQQVR 116_ ENSIE 121_ LRELE 126_ KKLKA 131_ AYMNK 136_ ERAAQ 141_ IAEKD 146_ AIKYE 151_ QMKRD 156_ AEIAK 161_ TMMEE 166_ HKRII 171_ KEENA 176_ AEDKR 181_ NKAKA 186_ QYYLD 191_ LEKQL 196_ EEQEK 201_ KKQEA 206_ YEQLL 211_ KEKLM 216_ IDEIV 221_ RKIYE 226_ EDQLE 231_ KQQKL 236_ EKMNA 241_ MRRYI 246_ EEFQK 251_ EQALW 256_ RKKKR 261_ EEMEE 266_ ENRKI 271_ IEFAN 276_ MQQQR 281_ EEDRM 286_ AKVQE 291_ NEEKR 296_ LQLQN 301_ ALTQK 306_ LEEML 311_ RQRED 316_ LEQVR 321_ QELYQ 326_ EEQAE 331_ IYKSK 336_ LKEEA 341_ EKKLR 346_ KQKEM 351_ KQDFE 356_ EQMAL 361_ KELVL 366_ QAAKE 371_ EEENF 376_ RKTML 381_ AKFAE 386_ DDRIE 391_ LMNAQ 396_ KQRMK 401_ QLEHR 406_ RAVEK 411_ LIEER 416_ RQQFL 421_ ADKQR 426_ ELEEW 431_ QLQQR 436_ RQGFI 441_ NAIIE 446_ EERLK 451_ LLKEH 456_ ATNLL 461_ GYLPK 466_ GVFKK 471_ EDDID 476_ LLGEE 481_ FRKVY 486_QQRSE

Protein annotations

Protein functions:

1: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:36191189). May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis. Required for sperm flagella assembly (By similarity). May play a role in the assembly and function of the outer dynein arm-docking complex (ODA-DC). ODA-DC mediates outer dynein arms (ODA) binding onto the axonemal doublet microtubules (PubMed:30148830)