Neuroguidin (Centromere accumulated nuclear protein 1) (CANu1) (EIF4E-binding protein)
1_MAALG 6_ VLESD 11_ LPSAV 16_ TLLKN 21_ LQEQV 26_ MAVTA 31_ QVKSL 36_ TQKVQ 41_ AGAYP 46_ TEKGL 51_ SFLEV 56_ KDQLL 61_ LMYLM 66_ DLTHL 71_ ILDKA 76_ SGGSL 81_ QGHDA 86_ VLRLV 91_ EIRTV 96_ LEKLR 101_ PLDQK 106_ LKYQI 111_ DKLIK 116_ TAVTG 121_ SLSEN 126_ DPLRF 131_ KPHPS 136_ NMMSK 141_ LSSED 146_ EEEDE 151_ AEDDQ 156_ SEASG 161_ KKSVK 166_ GVSKK 171_ YVPPR 176_ LVPVH 181_ YDETE 186_ AEREK 191_ KRLER 196_ AKRRA 201_ LSSSV 206_ IRELK 211_ EQYSD 216_ APEEI 221_ RDARH 226_ PHVTR 231_ QSQED 236_ QHRIN 241_ YEESM 246_ MVRLS 251_ VSKRE 256_ KGRRK 261_ RANVM 266_ SSQLH 271_ SLTHF 276_ SDISA 281_ LTGGT 286_ VHLDE 291_ DQNPI 296_ KKRKK 301_ IPQKG 306_RKKKG
1: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Its dissociation from the complex determines the transition from state pre-A1 to state pre-A1* (PubMed:34516797). Inhibits mRNA translation in a cytoplasmic polyadenylation element (CPE)-dependent manner (By similarity)