Phospholipase DDHD1 (EC 3.1.1.-) (DDHD domain-containing protein 1) (Phosphatidic acid-preferring phospholipase A1 homolog) (PA-PLA1)
1_MNYPG 6_ RGSPR 11_ SPEHN 16_ GRGGG 21_ GGAWE 26_ LGSDA 31_ RPAFG 36_ GGVCC 41_ FEHLP 46_ GGDPD 51_ DGDVP 56_ LALLR 61_ GEPGL 66_ HLAPG 71_ TDDHN 76_ HHLAL 81_ DPCLS 86_ DENYD 91_ FSSAE 96_ SGSSL 101_ RYYSE 106_ GESGG 111_ GGSSL 116_ SLHPP 121_ QQPPL 126_ VPTNS 131_ GGGGA 136_ TGGSP 141_ GERKR 146_ TRLGG 151_ PAARH 156_ RYEVV 161_ TELGP 166_ EEVRW 171_ FYKED 176_ KKTWK 181_ PFIGY 186_ DSLRI 191_ ELAFR 196_ TLLQT 201_ TGARP 206_ QGGDR 211_ DGDHV 216_ CSPTG 221_ PASSS 226_ GEDDD 231_ EDRAC 236_ GFCQS 241_ TTGHE 246_ PEMVE 251_ LVNIE 256_ PVCVR 261_ GGLYE 266_ VDVTQ 271_ GECYP 276_ VYWNQ 281_ ADKIP 286_ VMRGQ 291_ WFIDG 296_ TWQPL 301_ EEEES 306_ NLIEQ 311_ EHLNC 316_ FRGQQ 321_ MQENF 326_ DIEVS 331_ KSIDG 336_ KDAVH 341_ SFKLS 346_ RNHVD 351_ WHSVD 356_ EVYLY 361_ SDATT 366_ SKIAR 371_ TVTQK 376_ LGFSK 381_ ASSSG 386_ TRLHR 391_ GYVEE 396_ ATLED 401_ KPSQT 406_ THIVF 411_ VVHGI 416_ GQKMD 421_ QGRII 426_ KNTAM 431_ MREAA 436_ RKIEE 441_ RHFSN 446_ HATHV 451_ EFLPV 456_ EWRSK 461_ LTLDG 466_ DTVDS 471_ ITPDK 476_ VRGLR 481_ DMLNS 486_ SAMDI 491_ MYYTS 496_ PLYRD 501_ ELVKG 506_ LQQEL 511_ NRLYS 516_ LFCSR 521_ NPDFE 526_ EKGGK 531_ VSIVS 536_ HSLGC 541_ VITYD 546_ IMTGW 551_ NPVRL 556_ YEQLL 561_ QKEEE 566_ LPDER 571_ WMSYE 576_ ERHLL 581_ DELYI 586_ TKRRL 591_ KEIEE 596_ RLHGL 601_ KASSM 606_ TQTPA 611_ LKFKV 616_ ENFFC 621_ MGSPL 626_ AVFLA 631_ LRGIR 636_ PGNTG 641_ SQDHI 646_ LPREI 651_ CNRLL 656_ NIFHP 661_ TDPVA 666_ YRLEP 671_ LILKH 676_ YSNIS 681_ PVQIH 686_ WYNTS 691_ NPLPY 696_ EHMKP 701_ SFLNP 706_ AKEPT 711_ SVSEN 716_ EGIST 721_ IPSPV 726_ TSPVL 731_ SRRHY 736_ GESIT 741_ NIGKA 746_ SILGA 751_ ASIGK 756_ GLGGM 761_ LFSRF 766_ GRSST 771_ TQSSE 776_ TSKDS 781_ MEDEK 786_ KPVAS 791_ PSATT 796_ VGTQT 801_ LPHSS 806_ SGFLD 811_ SAYFR 816_ LQESF 821_ FNLPQ 826_ LLFPE 831_ NVMQN 836_ KDNAL 841_ VELDH 846_ RIDFE 851_ LREGL 856_ VESRY 861_ WSAVT 866_ SHTAY 871_ WSSLD 876_ VALFL 881_ LTFMY 886_ KHEHD 891_DDAKP
1: Phospholipase A1 (PLA1) that hydrolyzes ester bonds at the sn-1 position of glycerophospholipids producing a free fatty acid and a lysophospholipid (Probable) (PubMed:20359546, PubMed:22922100). Prefers phosphatidate (1,2-diacyl-sn-glycero-3-phosphate, PA) as substrate in vitro, but can efficiently hydrolyze phosphatidylinositol (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol), PI), as well as a range of other glycerophospholipid substrates such as phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE), phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) and phosphatidylglycerol (1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol), PG) (Probable) (PubMed:20359546). Involved in the regulation of the endogenous content of polyunsaturated PI and PS lipids in the nervous system. Changes in these lipids extend to downstream metabolic products like PI phosphates PIP and PIP2, which play fundamental roles in cell biology (By similarity). Regulates mitochondrial morphology (PubMed:24599962). These dynamic changes may be due to PA hydrolysis at the mitochondrial surface (PubMed:24599962). May play a regulatory role in spermatogenesis or sperm function (PubMed:24599962)