Activin receptor type-1C (EC 2.7.11.30) (Activin receptor type IC) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7)
1_MTRAL 6_ CSALR 11_ QALLL 16_ LAAAA 21_ ELSPG 26_ LKCVC 31_ LLCDS 36_ SNFTC 41_ QTEGA 46_ CWASV 51_ MLTNG 56_ KEQVI 61_ KSCVS 66_ LPELN 71_ AQVFC 76_ HSSNN 81_ VTKTE 86_ CCFTD 91_ FCNNI 96_ TLHLP 101_ TASPN 106_ APKLG 111_ PMELA 116_ IIITV 121_ PVCLL 126_ SIAAM 131_ LTVWA 136_ CQGRQ 141_ CSYRK 146_ KKRPN 151_ VEEPL 156_ SECNL 161_ VNAGK 166_ TLKDL 171_ IYDVT 176_ ASGSG 181_ SGLPL 186_ LVQRT 191_ IARTI 196_ VLQEI 201_ VGKGR 206_ FGEVW 211_ HGRWC 216_ GEDVA 221_ VKIFS 226_ SRDER 231_ SWFRE 236_ AEIYQ 241_ TVMLR 246_ HENIL 251_ GFIAA 256_ DNKDN 261_ GTWTQ 266_ LWLVS 271_ EYHEQ 276_ GSLYD 281_ YLNRN 286_ IVTVA 291_ GMIKL 296_ ALSIA 301_ SGLAH 306_ LHMEI 311_ VGTQG 316_ KPAIA 321_ HRDIK 326_ SKNIL 331_ VKKCE 336_ TCAIA 341_ DLGLA 346_ VKHDS 351_ ILNTI 356_ DIPQN 361_ PKVGT 366_ KRYMA 371_ PEMLD 376_ DTMNV 381_ NIFES 386_ FKRAD 391_ IYSVG 396_ LVYWE 401_ IARRC 406_ SVGGI 411_ VEEYQ 416_ LPYYD 421_ MVPSD 426_ PSIEE 431_ MRKVV 436_ CDQKF 441_ RPSIP 446_ NQWQS 451_ CEALR 456_ VMGRI 461_ MRECW 466_ YANGA 471_ ARLTA 476_ LRIKK 481_ TISQL 486_CVKED
1: Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consists of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B, activin E and NODAL. Upon NODAL binding, activation results in increased apoptosis and reduced proliferation through suppression of AKT signaling and the activation of Smad2-dependent signaling pathway in pancreatic beta-cells, trophoblasts, epithelial or neuronal cells (PubMed:15531507, PubMed:15150278). Acts as a positive regulator for macrophage activation partially through down-regulation of PPARG expression (By similarity)