Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe (EC 2.4.1.222) (O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase)
1_MLKRC 6_ GRRLL 11_ LALAG 16_ ALLAC 21_ LLVLT 26_ ADPPP 31_ PPLPA 36_ ERGRR 41_ ALRSL 46_ AGPAG 51_ AAPAP 56_ GLGAA 61_ AAAPG 66_ ALVRD 71_ VHSLS 76_ EYFSL 81_ LTRAR 86_ RDAGP 91_ PPGAA 96_ PRPAD 101_ GHPRP 106_ LAEPL 111_ APRDV 116_ FIAVK 121_ TTKKF 126_ HRARL 131_ DLLLE 136_ TWISR 141_ HKEMT 146_ FIFTD 151_ GEDEA 156_ LARHT 161_ GNVVI 166_ TNCSA 171_ AHSRQ 176_ ALSCK 181_ MAVEY 186_ DRFIE 191_ SGRKW 196_ FCHVD 201_ DDNYV 206_ NLRAL 211_ LRLLA 216_ SYPHT 221_ RDVYV 226_ GKPSL 231_ DRPIQ 236_ AMERV 241_ SENKV 246_ RPVHF 251_ WFATG 256_ GAGFC 261_ ISRGL 266_ ALKMS 271_ PWASG 276_ GHFMN 281_ TAERI 286_ RLPDD 291_ CTIGY 296_ IVEAL 301_ LGVPL 306_ IRSGL 311_ FHSHL 316_ ENLQQ 321_ VPTSE 326_ LHEQV 331_ TLSYG 336_ MFENK 341_ RNAVH 346_ VKGPF 351_ SVEAD 356_ PSRFR 361_ SIHCH 366_ LYPDT 371_PWCPR
1: Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1 (By similarity). Decreases the binding of JAG1 to NOTCH2 but not that of DLL1 (PubMed:11346656). Essential mediator of somite segmentation and patterning (By similarity)