NFAT activation molecule 1 (Calcineurin/NFAT-activating ITAM-containing protein) (NFAT-activating protein with ITAM motif 1)
1_MENQP 6_ VRWRA 11_ LPGLP 16_ RPPGL 21_ PAAPW 26_ LLLGV 31_ LLLPG 36_ TLRLA 41_ GGQSV 46_ THTGL 51_ PIMAS 56_ LANTA 61_ ISFSC 66_ RITYP 71_ YTPQF 76_ KVFTV 81_ SYFHE 86_ DLQGQ 91_ RSPKK 96_ PTNCH 101_ PGLGT 106_ ENQSH 111_ TLDCQ 116_ VTLVL 121_ PGASA 126_ TGTYY 131_ CSVHW 136_ PHSTV 141_ RGSGT 146_ FILVR 151_ DAGYR 156_ EPPQS 161_ PQKLL 166_ LFGFT 171_ GLLSV 176_ LSVVG 181_ TALLL 186_ WNKKR 191_ MRGPG 196_ KDPTR 201_ KCPDP 206_ RSASS 211_ PKQHP 216_ SESVY 221_ TALQR 226_ RETEV 231_ YACIE 236_ NEDGS 241_ SPTAK 246_ QSPLS 251_ QERPH 256_ RFEDD 261_GELNL
1: May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF-alpha promoters. May be involved in the regulation of B-cell, but not T-cell, development. Overexpression activates downstream effectors without ligand binding or antibody cross-linking