Transmembrane inner ear expressed protein
1_MAGWP 6_ GAGPL 11_ CVLGG 16_ AALGV 21_ CLAGV 26_ AGQLV 31_ EPSTA 36_ PPKPK 41_ PPPLT 46_ KETVV 51_ FWDMR 56_ LWHVV 61_ GIFSL 66_ FVLSI 71_ IITLC 76_ CVFNC 81_ RVPRT 86_ RKEIE 91_ ARYLQ 96_ RKAAK 101_ MYTDK 106_ LETVP 111_ PLNEL 116_ TEVPG 121_ EDKKK 126_ KKKKK 131_ KDSVD 136_ TVAIK 141_ VEEDE 146_ KNEAK 151_KKKGE
1: Auxiliary subunit of the mechanotransducer (MET) non-specific cation channel complex located at the tips of stereocilia of cochlear hair cells and that mediates sensory transduction in the auditory system. The MET complex is composed of two dimeric pore-forming ion-conducting transmembrane TMC (TMC1 or TMC2) subunits, and aided by several auxiliary proteins including LHFPL5, TMIE, CIB2/3 and TOMT, and the tip-link PCDH15. May contribute to the formation of the pore