Short-chain dehydrogenase/reductase family 9C member 7 (EC 1.1.1.-) (Orphan short-chain dehydrogenase/reductase) (SDR-O) (RDH-S)
1_MAALT 6_ DLSFM 11_ YRWFK 16_ NCNLV 21_ GNLSE 26_ KYVFI 31_ TGCDS 36_ GFGNL 41_ LAKQL 46_ VDRGM 51_ QVLAA 56_ CFTEE 61_ GSQKL 66_ QRDTS 71_ YRLQT 76_ TLLDV 81_ TKSES 86_ IKAAA 91_ QWVRD 96_ KVGEQ 101_ GLWAL 106_ VNNAG 111_ VGLPS 116_ GPNEW 121_ LTKDD 126_ FVKVI 131_ NVNLV 136_ GLIEV 141_ TLHML 146_ PMVKR 151_ ARGRV 156_ VNMSS 161_ SGGRV 166_ AVIGG 171_ GYCVS 176_ KFGVE 181_ AFSDS 186_ IRREL 191_ YYFGV 196_ KVCII 201_ EPGNY 206_ RTAIL 211_ GKENL 216_ ESRMR 221_ KLWER 226_ LPQET 231_ RDSYG 236_ EDYFR 241_ IYTDK 246_ LKNIM 251_ QVAEP 256_ RVRDV 261_ INSME 266_ HAIVS 271_ RSPRI 276_ RYNPG 281_ LDAKL 286_ LYIPL 291_ AKLPT 296_ PVTDF 301_ ILSRY 306_LPRPA
1: Plays a crucial role in the formation of the epidermal permeability barrier (PubMed:31671075). Catalyzes the NAD+-dependent dehydrogenation of the linoleate 9,10-trans-epoxy-11E-13-alcohol esterified in omega-O-acylceramides (such as in N-[omega-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecenoyloxy]-acylsphing-4E-enine) to the corresponding 13-ketone, the reactive moiety required for binding of epidermal ceramides to proteins (PubMed:31671075). Displays weak conversion of all-trans-retinal to all-trans-retinol in the presence of NADH. Has apparently no steroid dehydrogenase activity (PubMed:19703561)