Periphilin-1 (CDC7 expression repressor) (CR) (Gastric cancer antigen Ga50)
1_MWSEG 6_ RYEYE 11_ RIPRE 16_ RAPPR 21_ SHPSD 26_ GYNRL 31_ VNIVP 36_ KKPPL 41_ LDRPG 46_ EGSYN 51_ RYYSH 56_ VDYRD 61_ YDEGR 66_ SFSHD 71_ RRSGP 76_ PHRGD 81_ ESGYR 86_ WTRDD 91_ HSASR 96_ QPEYR 101_ DMRDG 106_ FRRKS 111_ FYSSH 116_ YARER 121_ SPYKR 126_ DNTFF 131_ RESPV 136_ GRKDS 141_ PHSRS 146_ GSSVS 151_ SRSYS 156_ PERSK 161_ SYSFH 166_ QSQHR 171_ KSVRP 176_ GASYK 181_ RQNEG 186_ NPERD 191_ KERPV 196_ QSLKT 201_ SRDTS 206_ PSSGS 211_ AVSSS 216_ KVLDK 221_ PSRLT 226_ EKELA 231_ EAASK 236_ WAAEK 241_ LEKSD 246_ ESNLP 251_ EISEY 256_ EAGST 261_ APLFT 266_ DQPEE 271_ PESNT 276_ THGIE 281_ LFEDS 286_ QLTTR 291_ SKAIA 296_ SKTKE 301_ IEQVY 306_ RQDCE 311_ TFGMV 316_ VKMLI 321_ EKDPS 326_ LEKSI 331_ QFALR 336_ QNLHE 341_ IESAG 346_ QTWQQ 351_ VPPVR 356_ NTEMD 361_ HDGTP 366_ ENEGE 371_ ETAQS 376_ APQPP 381_ QAPQP 386_ LQPRK 391_ KRVRR 396_ TTQLR 401_ RTTGA 406_ PDITW 411_ GMLKK 416_ TTQEA 421_ ERILL 426_ RTQTP 431_ FTPEN 436_ LFLAM 441_ LSVVH 446_ CNSRK 451_DVKPE
1: Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3. In the HUSH complex, contributes to the maintenance of the complex at chromatin (PubMed:26022416). Acts as a transcriptional corepressor and regulates the cell cycle, probably via the HUSH complex (PubMed:15474462, PubMed:17963697). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). May be involved in epithelial differentiation by contributing to epidermal integrity and barrier formation (PubMed:12853457)