F-box only protein 22 (F-box protein FBX22p44)
1_MEPVG 6_ CCGEC 11_ RGSSV 16_ DPRST 21_ FVLSN 26_ LAEVV 31_ ERVLT 36_ FLPAK 41_ ALLRV 46_ ACVCR 51_ LWREC 56_ VRRVL 61_ RTHRS 66_ VTWIS 71_ AGLAE 76_ AGHLE 81_ GHCLV 86_ RVVAE 91_ ELENV 96_ RILPH 101_ TVLYM 106_ ADSET 111_ FISLE 116_ ECRGH 121_ KRARK 126_ RTSME 131_ TALAL 136_ EKLFP 141_ KQCQV 146_ LGIVT 151_ PGIVV 156_ TPMGS 161_ GSNRP 166_ QEIEI 171_ GESGF 176_ ALLFP 181_ QIEGI 186_ KIQPF 191_ HFIKD 196_ PKNLT 201_ LERHQ 206_ LTEVG 211_ LLDNP 216_ ELRVV 221_ LVFGY 226_ NCCKV 231_ GASNY 236_ LQQVV 241_ STFSD 246_ MNIIL 251_ AGGQV 256_ DNLSS 261_ LTSEK 266_ NPLDI 271_ DASGV 276_ VGLSF 281_ SGHRI 286_ QSATV 291_ LLNED 296_ VSDEK 301_ TAEAA 306_ MQRLK 311_ AANIP 316_ EHNTI 321_ GFMFA 326_ CVGRG 331_ FQYYR 336_ AKGNV 341_ EADAF 346_ RKFFP 351_ SVPLF 356_ GFFGN 361_ GEIGC 366_ DRIVT 371_ GNFIL 376_ RKCNE 381_ VKDDD 386_ LFHSY 391_ TTIMA 396_LIHLG
1: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that is implicated in the control of various cellular processes such as cell cycle control, transcriptional regulation, DNA damage repair, and apoptosis. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function. Acts as a key regulator of histone methylation marks namely H3K9 and H3K36 methylation through the regulation of histone demethylase KDM4A protein levels (PubMed:21768309). In complex with KDM4A, also regulates the abundance of TP53 by targeting methylated TP53 for degradation at the late senescent stage (PubMed:26868148). Under oxidative stress, promotes the ubiquitination and degradation of BACH1. Mechanistically, reactive oxygen species (ROS) covalently modify cysteine residues on the bZIP domain of BACH1, leading to its release from chromatin and making it accessible to FBXO22 (PubMed:39504958). Upon amino acid depletion, mediates 'Lys-27'-linked ubiquitination of MTOR and thereby inhibits substrate recruitment to mTORC1 (PubMed:37979583). Also inhibits SARS-CoV-2 replication by inducing NSP5 degradation (PubMed:39223933)