Dedicator of cytokinesis protein 8
1_MATLP 6_ SAERR 11_ AFALK 16_ INRYS 21_ SAEIR 26_ KQFTL 31_ PPNLG 36_ QYHRQ 41_ SISTS 46_ GFPSL 51_ QLPQF 56_ YDPVE 61_ PVDFE 66_ GLLMT 71_ HLNSL 76_ DVQLA 81_ QELGD 86_ FTDDD 91_ LDVVF 96_ TPKEC 101_ RTLQP 106_ SLPEE 111_ GVELD 116_ PHVRD 121_ CVQTY 126_ IREWL 131_ IVNRK 136_ NQGSP 141_ EICGF 146_ KKTGS 151_ RKDFH 156_ KTLPK 161_ QTFES 166_ ETLEC 171_ SEPAA 176_ QAGPR 181_ HLNVL 186_ CDVSG 191_ KGPVT 196_ ACDFD 201_ LRSLQ 206_ PDKRL 211_ ENLLQ 216_ QVSAE 221_ DFEKQ 226_ NEEAR 231_ RTNRQ 236_ AELFA 241_ LYPSV 246_ DEEDA 251_ VEIRP 256_ VPECP 261_ KEHLG 266_ NRILV 271_ KLLTL 276_ KFEIE 281_ IEPLF 286_ ASIAL 291_ YDVKE 296_ RKKIS 301_ ENFHC 306_ DLNSD 311_ QFKGF 316_ LRAHT 321_ PSVAA 326_ SSQAR 331_ SAVFS 336_ VTYPS 341_ SDIYL 346_ VVKIE 351_ KVLQQ 356_ GEIGD 361_ CAEPY 366_ TVIKE 371_ SDGGK 376_ SKEKI 381_ EKLKL 386_ QAESF 391_ CQRLG 396_ KYRMP 401_ FAWAP 406_ ISLSS 411_ FFNVS 416_ TLERE 421_ VTDVD 426_ SVVGR 431_ SSVGE 436_ RRTLA 441_ QSRRL 446_ SERAL 451_ SLEEN 456_ GVGSN 461_ FKTST 466_ LSVSS 471_ FFKQE 476_ GDRLS 481_ DEDLF 486_ KFLAD 491_ YKRSS 496_ SLQRR 501_ VKSIP 506_ GLLRL 511_ EISTA 516_ PEIIN 521_ CCLTP 526_ EMLPV 531_ KPFPE 536_ NRTRP 541_ HKEIL 546_ EFPTR 551_ EVYVP 556_ HTVYR 561_ NLLYV 566_ YPQRL 571_ NFVNK 576_ LASAR 581_ NITIK 586_ IQFMC 591_ GEDAS 596_ NAMPV 601_ IFGKS 606_ SGPEF 611_ LQEVY 616_ TAVTY 621_ HNKSP 626_ DFYEE 631_ VKIKL 636_ PAKLT 641_ VNHHL 646_ LFTFY 651_ HISCQ 656_ QKQGA 661_ SVETL 666_ LGYSW 671_ LPILL 676_ NERLQ 681_ TGSYC 686_ LPVAL 691_ EKLPP 696_ NYSMH 701_ SAEKV 706_ PLQNP 711_ PIKWA 716_ EGHKG 721_ VFNIE 726_ VQAVS 731_ SVHTQ 736_ DNHLE 741_ KFFTL 746_ CHSLE 751_ SQVTF 756_ PIRVL 761_ DQKIS 766_ EMALE 771_ HELKL 776_ SIICL 781_ NSSRL 786_ EPLVL 791_ FLHLV 796_ LDKLF 801_ QLSVQ 806_ PMVIA 811_ GQTAN 816_ FSQFA 821_ FESVV 826_ AIANS 831_ LHNSK 836_ DLSKD 841_ QHGRN 846_ CLLAS 851_ YVHYV 856_ FRLPE 861_ VQRDV 866_ PKSGA 871_ PTALL 876_ DPRSY 881_ HTYGR 886_ TSAAA 891_ VSSKL 896_ LQARV 901_ MSSSN 906_ PDLAG 911_ THSAA 916_ DEEVK 921_ NIMSS 926_ KIADR 931_ NCSRM 936_ SYYCS 941_ GSSDA 946_ PSSPA 951_ APRPA 956_ SKKHF 961_ HEELA 966_ LQMVV 971_ STGMV 976_ RETVF 981_ KYAWF 986_ FFELL 991_ VKSMA 996_ QHVHN 1001_ MDKRD 1006_ SFRRT 1011_ RFSDR 1016_ FMDDI 1021_ TTIVN 1026_ VVTSE 1031_ IAALL 1036_ VKPQK 1041_ ENEQA 1046_ EKMNI 1051_ SLAFF 1056_ LYDLL 1061_ SLMDR 1066_ GFVFN 1071_ LIRHY 1076_ CSQLS 1081_ AKLSN 1086_ LPTLI 1091_ SMRLE 1096_ FLRIL 1101_ CSHEH 1106_ YLNLN 1111_ LFFMN 1116_ ADTAP 1121_ TSPCP 1126_ SISSQ 1131_ NSSSC 1136_ SSFQD 1141_ QKIAS 1146_ MFDLT 1151_ SEYRQ 1156_ QHFLT 1161_ GLLFT 1166_ ELAAA 1171_ LDAEG 1176_ EGISK 1181_ VQRKA 1186_ VSAIH 1191_ SLLSS 1196_ HDLDP 1201_ RCVKP 1206_ EVKVK 1211_ IAALY 1216_ LPLVG 1221_ IILDA 1226_ LPQLC 1231_ DFTVA 1236_ DTRRY 1241_ RTSGS 1246_ DEEQE 1251_ GAGAI 1256_ NQNVA 1261_ LAIAG 1266_ NNFNL 1271_ KTSGI 1276_ VLSSL 1281_ PYKQY 1286_ NMLNA 1291_ DTTRN 1296_ LMICF 1301_ LWIMK 1306_ NADQS 1311_ LIRKW 1316_ IADLP 1321_ STQLN 1326_ RILDL 1331_ LFICV 1336_ LCFEY 1341_ KGKQS 1346_ SDKVS 1351_ TQVLQ 1356_ KSRDV 1361_ KARLE 1366_ EALLR 1371_ GEGAR 1376_ GEMMR 1381_ RRAPG 1386_ NDRFP 1391_ GLNEN 1396_ LRWKK 1401_ EQTHW 1406_ RQANE 1411_ KLDKT 1416_ KAELD 1421_ QEALI 1426_ SGNLA 1431_ TEAHL 1436_ IILDM 1441_ QENII 1446_ QASSA 1451_ LDCKD 1456_ SLLGG 1461_ VLRVL 1466_ VNSLN 1471_ CDQST 1476_ TYLTH 1481_ CFATL 1486_ RALIA 1491_ KFGDL 1496_ LFEEE 1501_ VEQCF 1506_ DLCHQ 1511_ VLHHC 1516_ SSSMD 1521_ VTRSQ 1526_ ACATL 1531_ YLLMR 1536_ FSFGA 1541_ TSNFA 1546_ RVKMQ 1551_ VTMSL 1556_ ASLVG 1561_ RAPDF 1566_ NEEHL 1571_ RRSLR 1576_ TILAY 1581_ SEEDT 1586_ AMQMT 1591_ PFPTQ 1596_ VEELL 1601_ CNLNS 1606_ ILYDT 1611_ VKMRE 1616_ FQEDP 1621_ EMLMD 1626_ LMYRI 1631_ AKSYQ 1636_ ASPDL 1641_ RLTWL 1646_ QNMAE 1651_ KHTKK 1656_ KCYTE 1661_ AAMCL 1666_ VHAAA 1671_ LVAEY 1676_ LSMLE 1681_ DHSYL 1686_ PVGSV 1691_ SFQNI 1696_ SSNVL 1701_ EESVV 1706_ SEDTL 1711_ SPDED 1716_ GVCAG 1721_ QYFTE 1726_ SGLVG 1731_ LLEQA 1736_ AELFS 1741_ TGGLY 1746_ ETVNE 1751_ VYKLV 1756_ IPILE 1761_ AHREF 1766_ RKLTL 1771_ THSKL 1776_ QRAFD 1781_ SIVNK 1786_ DHKRM 1791_ FGTYF 1796_ RVGFF 1801_ GSKFG 1806_ DLDEQ 1811_ EFVYK 1816_ EPAIT 1821_ KLPEI 1826_ SHRLE 1831_ AFYGQ 1836_ CFGAE 1841_ FVEVI 1846_ KDSTP 1851_ VDKTK 1856_ LDPNK 1861_ AYIQI 1866_ TFVEP 1871_ YFDEY 1876_ EMKDR 1881_ VTYFE 1886_ KNFNL 1891_ RRFMY 1896_ TTPFT 1901_ LEGRP 1906_ RGELH 1911_ EQYRR 1916_ NTVLT 1921_ TMHAF 1926_ PYIKT 1931_ RISVI 1936_ QKEEF 1941_ VLTPI 1946_ EVAIE 1951_ DMKKK 1956_ TLQLA 1961_ VAINQ 1966_ EPPDA 1971_ KMLQM 1976_ VLQGS 1981_ VGATV 1986_ NQGPL 1991_ EVAQV 1996_ FLAEI 2001_ PADPK 2006_ LYRHH 2011_ NKLRL 2016_ CFKEF 2021_ IMRCG 2026_ EAVEK 2031_ NKRLI 2036_ TADQR 2041_ EYQQE 2046_ LKKNY 2051_ NKLKE 2056_ NLRPM 2061_ IERKI 2066_ PELYK 2071_ PIFRV 2076_ ESQKR 2081_ DSFHR 2086_ SSFRK 2091_CETQL
1: Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP (PubMed:22461490, PubMed:28028151). During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC (By similarity). Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane (PubMed:28028151). Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing (PubMed:25762780)