NADPH oxidase organizer 1 (NADPH oxidase regulatory protein) (Nox organizer 1) (Nox-organizing protein 1) (SH3 and PX domain-containing protein 5)
1_MAGPR 6_ YPVSV 11_ QGAAL 16_ VQIKR 21_ LQTFA 26_ FSVRW 31_ SDGSD 36_ TFVRR 41_ SWDEF 46_ RQLKK 51_ TLKET 56_ FPVEA 61_ GLLRR 66_ SDRVL 71_ PKLLG 76_ QASLD 81_ APLLG 86_ RVGRT 91_ SRGLA 96_ RLQLL 101_ ETYSR 106_ RLLAT 111_ AERVA 116_ RSPTI 121_ TGFFA 126_ PQPLD 131_ LEPAL 136_ PPGSR 141_ VILPT 146_ PEEQP 151_ LSRAA 156_ GRLSI 161_ HSLEA 166_ QSLRC 171_ LQPFC 176_ TQDTR 181_ DRPFQ 186_ AQAQE 191_ SLDVL 196_ LRHPS 201_ GWWLV 206_ ENEDR 211_ QTAWF 216_ PAPYL 221_ EEAAP 226_ GQGRE 231_ GGPSL 236_ GSSGP 241_ QFCAS 246_ RAYES 251_ SRADE 256_ LSVPA 261_ GARVR 266_ VLETS 271_ DRGWW 276_ LCRYG 281_ DRAGL 286_ LPAVL 291_ LRPEG 296_ LGALL 301_ SGTGF 306_ RGGDD 311_ PAGEA 316_ RGFPE 321_ PSQAT 326_ APPPT 331_ VPTRP 336_ SPGAI 341_ QSRCC 346_ TVTRR 351_ ALERR 356_ PRRQG 361_ RPRGC 366_ VDSVP 371_HPTTE
1: Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity