Class E basic helix-loop-helix protein 22 (bHLHe22) (Class B basic helix-loop-helix protein 5) (bHLHb5) (Trinucleotide repeat-containing gene 20 protein)
1_MERGM 6_ HLGAA 11_ AAGED 16_ DLFLH 21_ KSLSA 26_ STSKR 31_ LEAAF 36_ RSTPP 41_ GMDLS 46_ LAPPP 51_ RERPA 56_ SSSSS 61_ PLGCF 66_ EPADP 71_ EGAGL 76_ LLPPP 81_ GGGGG 86_ GSAGS 91_ GGGGG 96_ GGVGV 101_ PGLLV 106_ GSAGV 111_ GGDPS 116_ LSSLP 121_ AGAAL 126_ CLKYG 131_ ESASR 136_ GSVAE 141_ SSGGE 146_ QSPDD 151_ DSDGR 156_ CELVL 161_ RAGVA 166_ DPRAS 171_ PGAGG 176_ GGAKA 181_ AEGCS 186_ NAHLH 191_ GGASV 196_ PPGGL 201_ GGGGG 206_ GGSSS 211_ GSSGG 216_ GGGSG 221_ SGSGG 226_ SSSSS 231_ SSSSK 236_ KSKEQ 241_ KALRL 246_ NINAR 251_ ERRRM 256_ HDLND 261_ ALDEL 266_ RAVIP 271_ YAHSP 276_ SVRKL 281_ SKIAT 286_ LLLAK 291_ NYILM 296_ QAQAL 301_ EEMRR 306_ LVAYL 311_ NQGQA 316_ ISAAS 321_ LPSSA 326_ AAAAA 331_ AAALH 336_ PALGA 341_ YEQAA 346_ GYPFS 351_ AGLPP 356_ AASCP 361_ EKCAL 366_ FNSVS 371_ SSLCK 376_QCTEK
1: Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA (By similarity). In the brain, may function as an area-specific transcription factor that regulates the postmitotic acquisition of area identities and elucidate the genetic hierarchy between progenitors and postmitotic neurons driving neocortical arealization. May be required for the survival of a specific population of inhibitory neurons in the superficial laminae of the spinal cord dorsal horn that may regulate pruritis. Seems to play a crucial role in the retinogenesis, in the specification of amacrine and bipolar subtypes. Forms with PRDM8 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation