Bardet-Biedl syndrome 1 protein (BBS2-like protein 2)
1_MAAAS 6_ SSDSD 11_ ACGAE 16_ SNEAN 21_ SKWLD 26_ AHYDP 31_ MANIH 36_ TFSAC 41_ LALAD 46_ LHGDG 51_ EYKLV 56_ VGDLG 61_ PGGQQ 66_ PRLKV 71_ LKGPL 76_ VMTES 81_ PLPAL 86_ PAAAA 91_ TFLME 96_ QHEPR 101_ TPALA 106_ LASGP 111_ CVYVY 116_ KNLRP 121_ YFKFS 126_ LPQLP 131_ PNPLE 136_ QDLWN 141_ QAKED 146_ RIDPL 151_ TLKEM 156_ LESIR 161_ ETAEE 166_ PLSIQ 171_ SLRFL 176_ QLELS 181_ EMEAF 186_ VNQHK 191_ SNSIK 196_ RQTVI 201_ TTMTT 206_ LKKNL 211_ ADEDA 216_ VSCLV 221_ LGTEN 226_ KELLV 231_ LDPEA 236_ FTILA 241_ KMSLP 246_ SVPVF 251_ LEVSG 256_ QFDVE 261_ FRLAA 266_ ACRNG 271_ NIYIL 276_ RRDSK 281_ HPKYC 286_ IELSA 291_ QPVGL 296_ IRVHK 301_ VLVVG 306_ STQDS 311_ LHGFT 316_ HKGKK 321_ LWTVQ 326_ MPAAI 331_ LTMNL 336_ LEQHS 341_ RGLQA 346_ VMAGL 351_ ANGEV 356_ RIYRD 361_ KALLN 366_ VIHTP 371_ DAVTS 376_ LCFGR 381_ YGRED 386_ NTLIM 391_ TTRGG 396_ GLIIK 401_ ILKRT 406_ AVFVE 411_ GGSEV 416_ GPPPA 421_ QAMKL 426_ NVPRK 431_ TRLYV 436_ DQTLR 441_ EREAG 446_ TAMHR 451_ AFQTD 456_ LYLLR 461_ LRAAR 466_ AYLQA 471_ LESSL 476_ SPLST 481_ TAREP 486_ LKLHA 491_ VVQGL 496_ GPTFK 501_ LTLHL 506_ QNTST 511_ TRPVL 516_ GLLVC 521_ FLYNE 526_ ALYSL 531_ PRAFF 536_ KVPLL 541_ VPGLN 546_ YPLET 551_ FVESL 556_ SNKGI 561_ SDIIK 566_ VLVLR 571_ EGQSA 576_ PLLSA 581_ HVNMP 586_GSEGL
1: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization (PubMed:17574030, PubMed:22072986). Plays a role in olfactory cilium biogenesis/maintenance and trafficking (By similarity)