UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 (BGnT-7) (Beta-1,3-Gn-T7) (Beta-1,3-N-acetylglucosaminyltransferase 7) (Beta3Gn-T7) (EC 2.4.1.-)
1_MSLWK 6_ KTVYR 11_ SLCLA 16_ LALLV 21_ AVTVF 26_ QRSLT 31_ PGQFL 36_ QEPPP 41_ PTLEP 46_ QKAQK 51_ PNGQL 56_ VNPNN 61_ FWKNP 66_ KDVAA 71_ PTPMA 76_ SQGPQ 81_ AWDVT 86_ TTNCS 91_ ANINL 96_ THQPW 101_ FQVLE 106_ PQFRQ 111_ FLFYR 116_ HCRYF 121_ PMLLN 126_ HPEKC 131_ RGDVY 136_ LLVVV 141_ KSVIT 146_ QHDRR 151_ EAIRQ 156_ TWGRE 161_ RQSAG 166_ GGRGA 171_ VRTLF 176_ LLGTA 181_ SKQEE 186_ RTHYQ 191_ QLLAY 196_ EDRLY 201_ GDILQ 206_ WGFLD 211_ TFFNL 216_ TLKEI 221_ HFLKW 226_ LDIYC 231_ PHVPF 236_ IFKGD 241_ DDVFV 246_ NPTNL 251_ LEFLA 256_ DRQPQ 261_ ENLFV 266_ GDVLQ 271_ HARPI 276_ RRKDN 281_ KYYIP 286_ GALYG 291_ KASYP 296_ PYAGG 301_ GGFLM 306_ AGSLA 311_ RRLHH 316_ ACDTL 321_ ELYPI 326_ DDVFL 331_ GMCLE 336_ VLGVQ 341_ PTAHE 346_ GFKTF 351_ GISRN 356_ RNSRM 361_ NKEPC 366_ FFRAM 371_ LVVHK 376_ LLPPE 381_ LLAMW 386_ GLVHS 391_ NLTCS 396_RKLQV
1: N-acetyl glucosamine (GlcNAc) transferase that catalyzes the transfer of GlcNAc via a beta1->3 linkage from UDP-GlcNAc to the non-reducing terminal galactose (Gal) in the linearly growing chain of N- and O-linked keratan sulfate proteoglycans. Cooperates with B4GALT4 galactosyltransferase and CHST6 and CHST1 sulfotransferases to construct and elongate mono- and disulfated disaccharide units [->3Galbeta1->4(6-sulfoGlcNAcbeta)1->] and [->3(6-sulfoGalbeta)1->4(6-sulfoGlcNAcbeta)1->] within keratan sulfate polymer (PubMed:14706853, PubMed:17690104). Involved in biosynthesis of N-linked keratan sulfate proteoglycans in cornea, with an impact on proteoglycan fibril organization and corneal transparency (By similarity) (PubMed:17690104). May play a role in the maintenance of tissue architecture by suppressing cellular motility and invasion (By similarity)