Diphosphoinositol polyphosphate phosphohydrolase 3-alpha (DIPP-3-alpha) (DIPP3-alpha) (hDIPP3alpha) (EC 3.6.1.52) (Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-alpha) (Diadenosine hexaphosphate hydrolase (AMP-forming)) (EC 3.6.1.60) (Nucleoside diphosphate-linked moiety X motif 10) (Nudix motif 10) (hAps2)
1_MKCKP 6_ NQTRT 11_ YDPEG 16_ FKKRA 21_ ACLCF 26_ RSERE 31_ DEVLL 36_ VSSSR 41_ YPDRW 46_ IVPGG 51_ GMEPE 56_ EEPGG 61_ AAVRE 66_ VYEEA 71_ GVKGK 76_ LGRLL 81_ GVFEQ 86_ NQDPK 91_ HRTYV 96_ YVLTV 101_ TELLE 106_ DWEDS 111_ VSIGR 116_ KREWF 121_ KVEDA 126_ IKVLQ 131_ CHKPV 136_ HAEYL 141_ EKLKL 146_ GGSPT 151_ NGNSM 156_APSSP
1: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate