Metalloreductase STEAP2 (EC 1.16.1.-) (Prostate cancer-associated protein 1) (Protein up-regulated in metastatic prostate cancer) (PUMPCn) (Six-transmembrane epithelial antigen of prostate 2) (SixTransMembrane protein of prostate 1)
1_MESIS 6_ MMGSP 11_ KSLSE 16_ TFLPN 21_ GINGI 26_ KDARK 31_ VTVGV 36_ IGSGD 41_ FAKSL 46_ TIRLI 51_ RCGYH 56_ VVIGS 61_ RNPKF 66_ ASEFF 71_ PHVVD 76_ VTHHE 81_ DALTK 86_ TNIIF 91_ VAIHR 96_ EHYTS 101_ LWDLR 106_ HLLVG 111_ KILID 116_ VSNNM 121_ RINQY 126_ PESNA 131_ EYLAS 136_ LFPDS 141_ LIVKG 146_ FNVVS 151_ AWALQ 156_ LGPKD 161_ ASRQV 166_ YICSN 171_ NIQAR 176_ QQVIE 181_ LARQL 186_ NFIPI 191_ DLGSL 196_ SSARE 201_ IENLP 206_ LRLFT 211_ LWRGP 216_ VVVAI 221_ SLATF 226_ FFLYS 231_ FVRDV 236_ IHPYA 241_ RNQQS 246_ DFYKI 251_ PIEIV 256_ NKTLP 261_ IVAIT 266_ LLSLV 271_ YLAGL 276_ LAAAY 281_ QLYYG 286_ TKYRR 291_ FPPWL 296_ ETWLQ 301_ CRKQL 306_ GLLSF 311_ FFAMV 316_ HVAYS 321_ LCLPM 326_ RRSER 331_ YLFLN 336_ MAYQQ 341_ VHANI 346_ ENSWN 351_ EEEVW 356_ RIEMY 361_ ISFGI 366_ MSLGL 371_ LSLLA 376_ VTSIP 381_ SVSNA 386_ LNWRE 391_ FSFIQ 396_ STLGY 401_ VALLI 406_ STFHV 411_ LIYGW 416_ KRAFE 421_ EEYYR 426_ FYTPP 431_ NFVLA 436_ LVLPS 441_ IVILG 446_ KIILF 451_ LPCIS 456_ RKLKR 461_ IKKGW 466_ EKSQF 471_ LEEGM 476_ GGTIP 481_HVSPE
1: Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane (By similarity). Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (By similarity). Can also reduce Cu(2+) to Cu(1+) (By similarity)