Bestrophin-2 (Vitelliform macular dystrophy 2-like protein 1)
1_MTVTY 6_ TARVA 11_ NARFG 16_ GFSQL 21_ LLLWR 26_ GSIYK 31_ LLWRE 36_ LLCFL 41_ GFYMA 46_ LSAAY 51_ RFVLT 56_ EGQKR 61_ YFEKL 66_ VIYCD 71_ QYASL 76_ IPVSF 81_ VLGFY 86_ VTLVV 91_ NRWWS 96_ QYLCM 101_ PLPDA 106_ LMCVV 111_ AGTVH 116_ GRDDR 121_ GRLYR 126_ RTLMR 131_ YAGLS 136_ AVLIL 141_ RSVST 146_ AVFKR 151_ FPTID 156_ HVVEA 161_ GFMTR 166_ EERKK 171_ FENLN 176_ SSYNK 181_ YWVPC 186_ VWFSN 191_ LAAQA 196_ RREGR 201_ IRDNS 206_ ALKLL 211_ LEELN 216_ VFRGK 221_ CGMLF 226_ HYDWI 231_ SVPLV 236_ YTQVV 241_ TIALY 246_ SYFLA 251_ CLIGR 256_ QFLDP 261_ AQGYK 266_ DHDLD 271_ LCVPI 276_ FTLLQ 281_ FFFYA 286_ GWLKV 291_ AEQLI 296_ NPFGE 301_ DDDDF 306_ ETNFL 311_ IDRNF 316_ QVSML 321_ AVDEM 326_ YDDLA 331_ VLEKD 336_ LYWDA 341_ AEARA 346_ PYTAA 351_ TVFQL 356_ RQPSF 361_ QGSTF 366_ DITLA 371_ KEDMQ 376_ FQRLD 381_ GLDGP 386_ MGEAP 391_ GDFLQ 396_ RLLPA 401_ GAGMV 406_ AGGPL 411_ GRRLS 416_ FLLRK 421_ NSCVS 426_ EASTG 431_ ASCSC 436_ AVVPE 441_ GAAPE 446_ CSCGD 451_ PLLDP 456_ GLPEP 461_ EAPPP 466_ AGPEP 471_ LTLIP 476_ GPVEP 481_ FSIVT 486_ MPGPR 491_ GPAPP 496_ WLPSP 501_IGEEE
1: Ligand-gated anion channel that allows the movement of anions across cell membranes when activated by calcium (Ca2+) (PubMed:11904445, PubMed:18400985, PubMed:32251414, PubMed:35789156, PubMed:36289327). Transports a large specter of anions, namely mediates the movement of chloride, L-glutamate and iodide (PubMed:11904445, PubMed:18400985, PubMed:32251414, PubMed:35789156, PubMed:36289327). Calcium-binding triggers the dilation of the aperture, but calcium-dependent gating is only effective when the size of the passing anion is bigger than the closed aperture (By similarity). Mediates the calcium-activated hydrogencarbonate movement and participates in colonic hydrogencarbonate secretion concomitant with mucin secretion (By similarity). In non-pigmented epithelium (NPE), mediates the efflux of intracellular L-glutamate; binding of intracellular L-glutamate activates and open both the neck and the aperture of the channel, leading to L-glutamate exit promoting chloride influx movement from the extracellular side in trans (PubMed:36289327). Also exhibits a directional permeability for intracellular glutamine, in a similar manner as for L-glutamate (PubMed:36289327)