Inositol polyphosphate multikinase (EC 2.7.1.140) (EC 2.7.1.151) (EC 2.7.1.153) (Inositol 1,3,4,6-tetrakisphosphate 5-kinase)
1_MATEP 6_ PSPLR 11_ VEAPG 16_ PPEMR 21_ TSPAI 26_ ESTPE 31_ GTPQP 36_ AGGRL 41_ RFLNG 46_ CVPLS 51_ HQVAG 56_ HMYGK 61_ DKVGI 66_ LQHPD 71_ GTVLK 76_ QLQPP 81_ PRGPR 86_ ELEFY 91_ NMVYA 96_ ADCFD 101_ GVLLE 106_ LRKYL 111_ PKYYG 116_ IWSPP 121_ TAPND 126_ LYLKL 131_ EDVTH 136_ KFNKP 141_ CIMDV 146_ KIGQK 151_ SYDPF 156_ ASSEK 161_ IQQQV 166_ SKYPL 171_ MEEIG 176_ FLVLG 181_ MRVYH 186_ VHSDS 191_ YETEN 196_ QHYGR 201_ SLTKE 206_ TIKDG 211_ VSRFF 216_ HNGYC 221_ LRKDA 226_ VAASI 231_ QKIEK 236_ ILQWF 241_ ENQKQ 246_ LNFYA 251_ SSLLF 256_ VYEGS 261_ SQPTT 266_ TKLND 271_ RTLAE 276_ KFLSK 281_ GQLSD 286_ TEVLE 291_ YNNNF 296_ HVLSS 301_ TANGK 306_ IESSV 311_ GKSLS 316_ KMYAR 321_ HRKIY 326_ TKKHH 331_ SQTSL 336_ KVENL 341_ EQDNG 346_ WKSMS 351_ QEHLN 356_ GNVLS 361_ QLEKV 366_ FYHLP 371_ TGCQE 376_ IAEVE 381_ VRMID 386_ FAHVF 391_ PSNTI 396_ DEGYV 401_ YGLKH 406_ LISVL 411_RSILD
1: Inositol phosphate kinase with a broad substrate specificity (PubMed:12027805, PubMed:12223481, PubMed:28882892, PubMed:30420721, PubMed:30624931). Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) first to inositol 1,3,4,5-tetrakisphosphate and then to inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) (PubMed:12027805, PubMed:12223481, PubMed:28882892, PubMed:30624931). Phosphorylates inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4) (PubMed:12223481). Phosphorylates inositol 1,4,5,6-tetrakisphosphate (Ins(1,4,5,6)P4) (By similarity). Phosphorylates glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate to glycero-3-phospho-1D-myo-inositol 3,4,5-trisphosphate (PubMed:28882892, PubMed:30420721). Plays an important role in MLKL-mediated necroptosis via its role in the biosynthesis of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Binding of these highly phosphorylated inositol phosphates to MLKL mediates the release of an N-terminal auto-inhibitory region, leading to activation of the kinase. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (PubMed:29883610). Required for normal embryonic development, probably via its role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) and inositol hexakisphosphate (InsP6) (By similarity)