Protein ABHD11 (EC 3.-.-.-) (Alpha/beta hydrolase domain-containing protein 11) (Abhydrolase domain-containing protein 11) (Williams-Beuren syndrome chromosomal region 21 protein)
1_MRAGQ 6_ QLASM 11_ LRWTR 16_ AWRLP 21_ REGLG 26_ PHGPS 31_ FARVP 36_ VAPSS 41_ SSGGR 46_ GGAEP 51_ RPLPL 56_ SYRLL 61_ DGEAA 66_ LPAVV 71_ FLHGL 76_ FGSKT 81_ NFNSI 86_ AKILA 91_ QQTGR 96_ RVLTV 101_ DARNH 106_ GDSPH 111_ SPDMS 116_ YEIMS 121_ QDLQD 126_ LLPQL 131_ GLVPC 136_ VVVGH 141_ SMGGK 146_ TAMLL 151_ ALQRP 156_ ELVER 161_ LIAVD 166_ ISPVE 171_ STGVS 176_ HFATY 181_ VAAMR 186_ AINIA 191_ DELPR 196_ SRARK 201_ LADEQ 206_ LSSVI 211_ QDMAV 216_ RQHLL 221_ TNLVE 226_ VDGRF 231_ VWRVN 236_ LDALT 241_ QHLDK 246_ ILAFP 251_ QRQES 256_ YLGPT 261_ LFLLG 266_ GNSQF 271_ VHPSH 276_ HPEIM 281_ RLFPR 286_ AQMQT 291_ VPNAG 296_ HWIHA 301_ DRPQD 306_FIAAI
1: Catalyzes the hydrolysis of diacylglycerol in vitro and may function as a key regulator in lipid metabolism, namely by regulating the intracellular levels of diacylglycerol (PubMed:32579589). 1,2-diacyl-sn-glycerols are the preferred substrate over 1,3-diacyl-sn-glycerols (By similarity). The enzyme hydrolyzes stearate in preference to palmitate from the sn-1 position of 1,2-diacyl-sn-glycerols (By similarity). Maintains the functional lipoylation of the 2-oxoglutarate dehydrogenase complex (OGDHc) through its interaction with the OGDHc by preventing the formation of lipoyl adducts (PubMed:32792488). In addition, is also required for the expansion and differentiation of embryonic stem cells (ESCs) (By similarity)