N-acylneuraminate cytidylyltransferase (EC 2.7.7.43) (CMP-N-acetylneuraminic acid synthase) (CMP-NeuNAc synthase)
1_MDSVE 6_ KGAAT 11_ SVSNP 16_ RGRPS 21_ RGRPP 26_ KLQRN 31_ SRGGQ 36_ GRGVE 41_ KPPHL 46_ AALIL 51_ ARGGS 56_ KGIPL 61_ KNIKH 66_ LAGVP 71_ LIGWV 76_ LRAAL 81_ DSGAF 86_ QSVWV 91_ STDHD 96_ EIENV 101_ AKQFG 106_ AQVHR 111_ RSSEV 116_ SKDSS 121_ TSLDA 126_ IIEFL 131_ NYHNE 136_ VDIVG 141_ NIQAT 146_ SPCLH 151_ PTDLQ 156_ KVAEM 161_ IREEG 166_ YDSVF 171_ SVVRR 176_ HQFRW 181_ SEIQK 186_ GVREV 191_ TEPLN 196_ LNPAK 201_ RPRRQ 206_ DWDGE 211_ LYENG 216_ SFYFA 221_ KRHLI 226_ EMGYL 231_ QGGKM 236_ AYYEM 241_ RAEHS 246_ VDIDV 251_ DIDWP 256_ IAEQR 261_ VLRYG 266_ YFGKE 271_ KLKEI 276_ KLLVC 281_ NIDGC 286_ LTNGH 291_ IYVSG 296_ DQKEI 301_ ISYDV 306_ KDAIG 311_ ISLLK 316_ KSGIE 321_ VRLIS 326_ ERACS 331_ KQTLS 336_ SLKLD 341_ CKMEV 346_ SVSDK 351_ LAVVD 356_ EWRKE 361_ MGLCW 366_ KEVAY 371_ LGNEV 376_ SDEEC 381_ LKRVG 386_ LSGAP 391_ ADACS 396_ TAQKA 401_ VGYIC 406_ KCNGG 411_ RGAIR 416_ EFAEH 421_ ICLLM 426_EKVNN
1: Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN)