Kelch repeat and BTB domain-containing protein 8 (T-cell activation kelch repeat protein) (TA-KRP)
1_MAASA 6_ DLSKS 11_ SPTPN 16_ GIPSS 21_ DPASD 26_ AMDPF 31_ HACSI 36_ LKQLK 41_ TMYDE 46_ GQLTD 51_ IVVEV 56_ DHGKT 61_ FSCHR 66_ NVLAA 71_ ISPYF 76_ RSMFT 81_ SGLTE 86_ STQKE 91_ VRIVG 96_ VEAES 101_ MDLVL 106_ NYAYT 111_ SRVIL 116_ TEANV 121_ QALFT 126_ AASIF 131_ QIPSI 136_ QDQCA 141_ KYMIS 146_ HLDPQ 151_ NSIGV 156_ FIFAD 161_ HYGHQ 166_ ELGDR 171_ SKEYI 176_ RKKFL 181_ CVTKE 186_ QEFLQ 191_ LTKDQ 196_ LISIL 201_ DSDDL 206_ NVDRE 211_ EHVYE 216_ SIIRW 221_ FEHEQ 226_ NEREV 231_ HLPEI 236_ FAKCI 241_ RFPLM 246_ EDTFI 251_ EKIPP 256_ QFAQA 261_ IAKSC 266_ VEKGP 271_ SNTNG 276_ CTQRL 281_ GMTAS 286_ EMIIC 291_ FDAAH 296_ KHSGK 301_ KQTVP 306_ CLDIV 311_ TGRVF 316_ KLCKP 321_ PNDLR 326_ EVGIL 331_ VSPDN 336_ DIYIA 341_ GGYRP 346_ SSSEV 351_ SIDHK 356_ AENDF 361_ WMYDH 366_ STNRW 371_ LSKPS 376_ LLRAR 381_ IGCKL 386_ VYCCG 391_ KMYAI 396_ GGRVY 401_ EGDGR 406_ NSLKS 411_ VECYD 416_ SRENC 421_ WTTVC 426_ AMPVA 431_ MEFHN 436_ AVEYK 441_ EKIYV 446_ LQGEF 451_ FLFYE 456_ PQKDY 461_ WGFLT 466_ PMTVP 471_ RIQGL 476_ AAVYK 481_ DSIYY 486_ IAGTC 491_ GNHQR 496_ MFTVE 501_ AYDIE 506_ LNKWT 511_ RKKDF 516_ PCDQS 521_ INPYL 526_ KLVLF 531_ QNKLH 536_ LFVRA 541_ TQVTV 546_ EEHVF 551_ RTSRK 556_ NSLYQ 561_ YDDIA 566_ DQWMK 571_ VYETP 576_ DRLWD 581_ LGRHF 586_ ECAVA 591_ KLYPQ 596_CLQKV
1: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification (PubMed:26399832). The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832)