F-box DNA helicase 1 (hFBH1) (EC 3.6.4.12) (F-box only protein 18)
1_MRRFK 6_ RKHLT 11_ AIDCQ 16_ HLARS 21_ HLAVT 26_ QPFGQ 31_ RWTNR 36_ DPNHG 41_ LYPKP 46_ RTKRG 51_ SRGQG 56_ SQRCI 61_ PEFFL 66_ AGKQP 71_ CTNDM 76_ AKSNS 81_ VGQDS 86_ CQDSE 91_ GDMIF 96_ PAESS 101_ CALPQ 106_ EGSAG 111_ PGSPG 116_ SAPPS 121_ RKRSW 126_ SSEEE 131_ SNQAT 136_ GTSRW 141_ DGVSK 146_ KAPRH 151_ HLSVP 156_ CTRPR 161_ EARQE 166_ AEDST 171_ SRLSA 176_ ESGET 181_ DQDAG 186_ DVGPD 191_ PIPDS 196_ YYGLL 201_ GTLPC 206_ QEALS 211_ HICSL 216_ PSEVL 221_ RHVFA 226_ FLPVE 231_ DLYWN 236_ LSLVC 241_ HLWRE 246_ IISDP 251_ LFIPW 256_ KKLYH 261_ RYLMN 266_ EEQAV 271_ SKVDG 276_ ILSNC 281_ GIEKE 286_ SDLCV 291_ LNLIR 296_ YTATT 301_ KCSPS 306_ VDPER 311_ VLWSL 316_ RDHPL 321_ LPEAE 326_ ACVRQ 331_ HLPDL 336_ YAAAG 341_ GVNIW 346_ ALVAA 351_ VVLLS 356_ SSVND 361_ IQRLL 366_ FCLRR 371_ PSSTV 376_ TMPDV 381_ TETLY 386_ CIAVL 391_ LYAMR 396_ EKGIN 401_ ISNRI 406_ HYNIF 411_ YCLYL 416_ QENSC 421_ TQATK 426_ VKEEP 431_ SVWPG 436_ KKTIQ 441_ LTHEQ 446_ QLILN 451_ HKMEP 456_ LQVVK 461_ IMAFA 466_ GTGKT 471_ STLVK 476_ YAEKW 481_ SQSRF 486_ LYVTF 491_ NKSIA 496_ KQAER 501_ VFPSN 506_ VICKT 511_ FHSMA 516_ YGHIG 521_ RKYQS 526_ KKKLN 531_ LFKLT 536_ PFMVN 541_ SVLAE 546_ GKGGF 551_ IRAKL 556_ VCKTL 561_ ENFFA 566_ SADEE 571_ LTIDH 576_ VPIWC 581_ KNSQG 586_ QRVMV 591_ EQSEK 596_ LNGVL 601_ EASRL 606_ WDNMR 611_ KLGEC 616_ TEEAH 621_ QMTHD 626_ GYLKL 631_ WQLSK 636_ PSLAS 641_ FDAIF 646_ VDEAQ 651_ DCTPA 656_ IMNIV 661_ LSQPC 666_ GKIFV 671_ GDPHQ 676_ QIYTF 681_ RGAVN 686_ ALFTV 691_ PHTHV 696_ FYLTQ 701_ SFRFG 706_ VEIAY 711_ VGATI 716_ LDVCK 721_ RVRKK 726_ TLVGG 731_ NHQSG 736_ IRGDA 741_ KGQVA 746_ LLSRT 751_ NANVF 756_ DEAVR 761_ VTEGE 766_ FPSRI 771_ HLIGG 776_ IKSFG 781_ LDRII 786_ DIWIL 791_ LQPEE 796_ ERRKQ 801_ NLVIK 806_ DKFIR 811_ RWVHK 816_ EGFSG 821_ FKRYV 826_ TAAED 831_ KELEA 836_ KIAVV 841_ EKYNI 846_ RIPEL 851_ VQRIE 856_ KCHIE 861_ DLDFA 866_ EYILG 871_ TVHKA 876_ KGLEF 881_ DTVHV 886_ LDDFV 891_ KVPCA 896_ RHNLP 901_ QLPHF 906_ RVESF 911_ SEDEW 916_ NLLYV 921_ AVTRA 926_ KKRLI 931_ MTKSL 936_ ENILT 941_ LAGEY 946_ FLQAE 951_ LTSNV 956_ LKTGV 961_ VRCCV 966_ GQCNN 971_ AIPVD 976_ TVLTM 981_ KKLPI 986_ TYSNR 991_ KENKG 996_ GYLCH 1001_ SCAEQ 1006_ RIGPL 1011_ AFLTA 1016_ SPEQV 1021_ RAMER 1026_ TVENI 1031_ VLPRH 1036_EALLF
1: 3'-5' DNA helicase and substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks (PubMed:11956208, PubMed:23393192). Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination (PubMed:17724085, PubMed:19736316). Also promotes cell death and DNA double-strand breakage in response to replication stress: together with MUS81, promotes the endonucleolytic DNA cleavage following prolonged replication stress via its helicase activity, possibly to eliminate cells with excessive replication stress (PubMed:23319600, PubMed:23361013). Plays a major role in remodeling of stalled DNA forks by catalyzing fork regression, in which the fork reverses and the two nascent DNA strands anneal (PubMed:25772361). In addition to the helicase activity, also acts as the substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex, a complex that mediates ubiquitination of RAD51, leading to regulate RAD51 subcellular location (PubMed:25585578)