Neuroligin-2
1_MWLLA 6_ LCLVG 11_ LAGAQ 16_ RGGGG 21_ PGGGA 26_ PGGPG 31_ LGLGS 36_ LGEER 41_ FPVVN 46_ TAYGR 51_ VRGVR 56_ RELNN 61_ EILGP 66_ VVQFL 71_ GVPYA 76_ TPPLG 81_ ARRFQ 86_ PPEAP 91_ ASWPG 96_ VRNAT 101_ TLPPA 106_ CPQNL 111_ HGALP 116_ AIMLP 121_ VWFTD 126_ NLEAA 131_ ATYVQ 136_ NQSED 141_ CLYLN 146_ LYVPT 151_ EDGPL 156_ TKKRD 161_ EATLN 166_ PPDTD 171_ IRDPG 176_ KKPVM 181_ LFLHG 186_ GSYME 191_ GTGNM 196_ FDGSV 201_ LAAYG 206_ NVIVA 211_ TLNYR 216_ LGVLG 221_ FLSTG 226_ DQAAK 231_ GNYGL 236_ LDQIQ 241_ ALRWL 246_ SENIA 251_ HFGGD 256_ PERIT 261_ IFGSG 266_ AGASC 271_ VNLLI 276_ LSHHS 281_ EGLFQ 286_ KAIAQ 291_ SGTAI 296_ SSWSV 301_ NYQPL 306_ KYTRL 311_ LAAKV 316_ GCDRE 321_ DSAEA 326_ VECLR 331_ RKPSR 336_ ELVDQ 341_ DVQPA 346_ RYHIA 351_ FGPVV 356_ DGDVV 361_ PDDPE 366_ ILMQQ 371_ GEFLN 376_ YDMLI 381_ GVNQG 386_ EGLKF 391_ VEDSA 396_ ESEDG 401_ VSASA 406_ FDFTV 411_ SNFVD 416_ NLYGY 421_ PEGKD 426_ VLRET 431_ IKFMY 436_ TDWAD 441_ RDNGE 446_ MRRKT 451_ LLALF 456_ TDHQW 461_ VAPAV 466_ ATAKL 471_ HADYQ 476_ SPVYF 481_ YTFYH 486_ HCQAE 491_ GRPEW 496_ ADAAH 501_ GDELP 506_ YVFGV 511_ PMVGA 516_ TDLFP 521_ CNFSK 526_ NDVML 531_ SAVVM 536_ TYWTN 541_ FAKTG 546_ DPNQP 551_ VPQDT 556_ KFIHT 561_ KPNRF 566_ EEVVW 571_ SKFNS 576_ KEKQY 581_ LHIGL 586_ KPRVR 591_ DNYRA 596_ NKVAF 601_ WLELV 606_ PHLHN 611_ LHTEL 616_ FTTTT 621_ RLPPY 626_ ATRWP 631_ PRPPA 636_ GAPGT 641_ RRPPP 646_ PATLP 651_ PEPEP 656_ EPGPR 661_ AYDRF 666_ PGDSR 671_ DYSTE 676_ LSVTV 681_ AVGAS 686_ LLFLN 691_ ILAFA 696_ ALYYK 701_ RDRRQ 706_ ELRCR 711_ RLSPP 716_ GGSGS 721_ GVPGG 726_ GPLLP 731_ AAGRE 736_ LPPEE 741_ ELVSL 746_ QLKRG 751_ GGVGA 756_ DPAEA 761_ LRPAC 766_ PPDYT 771_ LALRR 776_ APDDV 781_ PLLAP 786_ GALTL 791_ LPSGL 796_ GPPPP 801_ PPPPS 806_ LHPFG 811_ PFPPP 816_ PPTAT 821_ SHNNT 826_LPHPH
1: Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Promotes clustering of postsynaptic LHFPL4 (By similarity). Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion (By similarity)