TNFAIP3-interacting protein 2 (A20-binding inhibitor of NF-kappa-B activation 2) (ABIN-2) (Fetal liver LKB1-interacting protein)
1_MSRDP 6_ GSGGW 11_ EEAPR 16_ AAAAL 21_ CTLYH 26_ EAGQR 31_ LRRLQ 36_ DQLAA 41_ RDALI 46_ ARLRA 51_ RLAAL 56_ EGDAA 61_ PSLVD 66_ ALLEQ 71_ VARFR 76_ EQLRR 81_ QEGGA 86_ AEAQM 91_ RQEIE 96_ RLTER 101_ LEEKE 106_ REMQQ 111_ LLSQP 116_ QHERE 121_ KEVVL 126_ LRRSM 131_ AEGER 136_ ARAAS 141_ DVLCR 146_ SLANE 151_ THQLR 156_ RTLTA 161_ TAHMC 166_ QHLAK 171_ CLDER 176_ QHAQR 181_ NVGER 186_ SPDQS 191_ EHTDG 196_ HTSVQ 201_ SVIEK 206_ LQEEN 211_ RLLKQ 216_ KVTHV 221_ EDLNA 226_ KWQRY 231_ NASRD 236_ EYVRG 241_ LHAQL 246_ RGLQI 251_ PHEPE 256_ LMRKE 261_ ISRLN 266_ RQLEE 271_ KINDC 276_ AEVKQ 281_ ELAAS 286_ RTARD 291_ AALER 296_ VQMLE 301_ QQILA 306_ YKDDF 311_ MSERA 316_ DRERA 321_ QSRIQ 326_ ELEEK 331_ VASLL 336_ HQVSW 341_ RQDSR 346_ EPDAG 351_ RIHAG 356_ SKTAK 361_ YLAAD 366_ ALELM 371_ VPGGW 376_ RPGTG 381_ SQQPE 386_ PPAEG 391_ GHPGA 396_ AQRGQ 401_ GDLQC 406_ PHCLQ 411_ CFSDE 416_ QGEEL 421_LRHVA
1: Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes