E3 ubiquitin-protein ligase TRIM58 (EC 2.3.2.27) (Protein BIA2) (RING-type E3 ubiquitin transferase TRIM58) (Tripartite motif-containing protein 58)
1_MAWAP 6_ PGERL 11_ REDAR 16_ CPVCL 21_ DFLQE 26_ PVSVD 31_ CGHSF 36_ CLRCI 41_ SEFCE 46_ KSDGA 51_ QGGVY 56_ ACPQC 61_ RGPFR 66_ PSGFR 71_ PNRQL 76_ AGLVE 81_ SVRRL 86_ GLGAG 91_ PGARR 96_ CARHG 101_ EDLSR 106_ FCEED 111_ EAALC 116_ WVCDA 121_ GPEHR 126_ THRTA 131_ PLQEA 136_ AGSYQ 141_ VKLQM 146_ ALELM 151_ RKELE 156_ DALTQ 161_ EANVG 166_ KKTVI 171_ WKEKV 176_ EMQRQ 181_ RFRLE 186_ FEKHR 191_ GFLAQ 196_ EEQRQ 201_ LRRLE 206_ AEERA 211_ TLQRL 216_ RESKS 221_ RLVQQ 226_ SKALK 231_ ELADE 236_ LQERC 241_ QRPAL 246_ GLLEG 251_ VRGVL 256_ SRSKA 261_ VTRLE 266_ AENIP 271_ MELKT 276_ ACCIP 281_ GRREL 286_ LRKFQ 291_ VDVKL 296_ DPATA 301_ HPSLL 306_ LTADL 311_ RSVQD 316_ GEPWR 321_ DVPNN 326_ PERFD 331_ TWPCI 336_ LGLQS 341_ FSSGR 346_ HYWEV 351_ LVGEG 356_ AEWGL 361_ GVCQD 366_ TLPRK 371_ GETTP 376_ SPENG 381_ VWALW 386_ LLKGN 391_ EYMVL 396_ ASPSV 401_ PLLQL 406_ ESPRC 411_ IGIFL 416_ DYEAG 421_ EISFY 426_ NVTDG 431_ SYIYT 436_ FNQLF 441_ SGLLR 446_ PYFFI 451_ CDATP 456_ LILPP 461_ TTIAG 466_ SGNWA 471_ SRDHL 476_ DPASD 481_VRDDH
1: E3 ubiquitin ligase induced during late erythropoiesis. Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complex. May participate in the erythroblast enucleation process through regulation of nuclear polarization