DNA helicase B (hDHB) (EC 3.6.4.12)
1_MARSS 6_ PYLRQ 11_ LQGPL 16_ LPPRD 21_ LVEED 26_ DDYLN 31_ DDVEE 36_ DEESV 41_ FIDAE 46_ ELCSG 51_ GVKAG 56_ SLPGC 61_ LRVSI 66_ CDENT 71_ QETCK 76_ VFGRF 81_ PITGA 86_ WWRVK 91_ VQVKP 96_ VVGSR 101_ SYQYQ 106_ VQGFP 111_ SYFLQ 116_ SDMSP 121_ PNQKH 126_ ICALF 131_ LKECE 136_ VSSDD 141_ VNKFL 146_ TWVKE 151_ VSNYK 156_ NLNFE 161_ NLRET 166_ LRTFH 171_ KETGR 176_ KDQKQ 181_ PTQNG 186_ QEELF 191_ LDNEM 196_ SLPLE 201_ NTIPF 206_ RNVMT 211_ ALQFP 216_ KIMEF 221_ LPVLL 226_ PRHFK 231_ WIIGS 236_ GSKEM 241_ LKEIE 246_ EILGT 251_ HPWKL 256_ GFSKI 261_ TYREW 266_ KLLRC 271_ EASWI 276_ AFCQC 281_ ESLLQ 286_ LMTDL 291_ EKNAL 296_ IMYSR 301_ LKQIC 306_ REDGH 311_ TYVEV 316_ NDLTL 321_ TLSNH 326_ MSFHA 331_ ASESL 336_ KFLKD 341_ IGVVT 346_ YEKSC 351_ VFPYD 356_ LYHAE 361_ RAIAF 366_ SICDL 371_ MKKPP 376_ WHLCV 381_ DVEKV 386_ LASIH 391_ TTKPE 396_ NSSDD 401_ ALNES 406_ KPDEV 411_ RLENP 416_ VDVVD 421_ TQDNG 426_ DHIWT 431_ NGENE 436_ INAEI 441_ SEVQL 446_ DQDQV 451_ EVPLD 456_ RDQVA 461_ ALEMI 466_ CSNPV 471_ TVISG 476_ KGGCG 481_ KTTIV 486_ SRLFK 491_ HIEQL 496_ EEREV 501_ KKACE 506_ DFEQD 511_ QNASE 516_ EWITF 521_ TEQSQ 526_ LEADK 531_ AIEVL 536_ LTAPT 541_ GKAAG 546_ LLRQK 551_ TGLHA 556_ YTLCQ 561_ VNYSF 566_ YSWTQ 571_ TMMTT 576_ NKPWK 581_ FSSVR 586_ VLVVD 591_ EGSLV 596_ SVGIF 601_ KSVLN 606_ LLCEH 611_ SKLSK 616_ LIILG 621_ DIRQL 626_ PSIEP 631_ GNLLK 636_ DLFET 641_ LKSRN 646_ CAIEL 651_ KTNHR 656_ AESQL 661_ IVDNA 666_ TRISR 671_ RQFPK 676_ FDAEL 681_ NISDN 686_ PTLPI 691_ SIQDK 696_ TFIFV 701_ RLPEE 706_ DASSQ 711_ SSKTN 716_ HHSCL 721_ YSAVK 726_ TLLQE 731_ NNLQN 736_ AKTSQ 741_ FIAFR 746_ RQDCD 751_ LINDC 756_ CCKHY 761_ TGHLT 766_ KDHQS 771_ RLVFG 776_ IGDKI 781_ CCTRN 786_ AYLSD 791_ LLPEN 796_ ISGSQ 801_ QNNDL 806_ DASSE 811_ DFSGT 816_ LPDFA 821_ KNKRD 826_ FESNV 831_ RLCNG 836_ EIFFI 841_ TNDVT 846_ DVTFG 851_ KRRSL 856_ TINNM 861_ AGLEV 866_ TVDFK 871_ KLMKY 876_ CRIKH 881_ AWART 886_ IHTFQ 891_ GSEEQ 896_ TVVYV 901_ VGKAG 906_ RQHWQ 911_ HVYTA 916_ VTRGR 921_ CRVYV 926_ IAEES 931_ QLRNA 936_ IMKNS 941_ FPRKT 946_ RLKHF 951_ LQSKL 956_ SSSGA 961_ PPADF 966_ PSPRK 971_ SSGDS 976_ GGPST 981_ PSASP 986_ LPVVT 991_ DHAMT 996_ NDVTW 1001_ SEASS 1006_ PDERT 1011_ LTFAE 1016_ RWQLS 1021_ SPDGV 1026_ DTDDD 1031_ LPKSR 1036_ ASKRT 1041_ CGVND 1046_ DESPS 1051_ KIFMV 1056_ GESPQ 1061_ VSSRL 1066_ QNLRL 1071_ NNLIP 1076_ RQLFK 1081_PTDNQ
1: 5'-3' DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection (PubMed:25617833, PubMed:26774285). Recruitment to single-stranded DNA (ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5'-3' ssDNA translocase activity of HELB (PubMed:26774285). As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation (PubMed:26774285). Acts independently of TP53BP1 (PubMed:26774285). Unwinds duplex DNA with 5'-3' polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates (PubMed:12181327). During S phase, may facilitate cellular recovery from replication stress (PubMed:22194613)