Gene name: TSPAN14

Uniprot entry:

Q8NG11

Protein names:

Tetraspanin-14 (Tspan-14) (DC-TM4F2) (Transmembrane 4 superfamily member 14)

Protein sequence:

1_MHYYR 6_ YSNAK 11_ VSCWY 16_ KYLLF 21_ SYNII 26_ FWLAG 31_ VVFLG 36_ VGLWA 41_ WSEKG 46_ VLSDL 51_ TKVTR 56_ MHGID 61_ PVVLV 66_ LMVGV 71_ VMFTL 76_ GFAGC 81_ VGALR 86_ ENICL 91_ LNFFC 96_ GTIVL 101_ IFFLE 106_ LAVAV 111_ LAFLF 116_ QDWVR 121_ DRFRE 126_ FFESN 131_ IKSYR 136_ DDIDL 141_ QNLID 146_ SLQKA 151_ NQCCG 156_ AYGPE 161_ DWDLN 166_ VYFNC 171_ SGASY 176_ SREKC 181_ GVPFS 186_ CCVPD 191_ PAQKV 196_ VNTQC 201_ GYDVR 206_ IQLKS 211_ KWDES 216_ IFTKG 221_ CIQAL 226_ ESWLP 231_ RNIYI 236_ VAGVF 241_ IAISL 246_ LQIFG 251_ IFLAR 256_ TLISD 261_IEAVK

Protein annotations

Protein functions:

1: Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates (PubMed:23035126, PubMed:26668317, PubMed:26686862, PubMed:37516108). Negatively regulates ADAM10-mediated cleavage of GP6 (By similarity). Promotes ADAM10-mediated cleavage of CDH5 (By similarity)