Kinetochore scaffold 1 (ALL1-fused gene from chromosome 15q14 protein) (AF15q14) (Bub-linking kinetochore protein) (Blinkin) (Cancer susceptibility candidate gene 5 protein) (Cancer/testis antigen 29) (CT29) (Kinetochore-null protein 1) (Protein CASC5) (Protein D40/AF15q14)
1_MDGVS 6_ SEANE 11_ ENDNI 16_ ERPVR 21_ RRHSS 26_ ILKPP 31_ RSPLQ 36_ DLRGG 41_ NERVQ 46_ ESNAL 51_ RNKKN 56_ SRRVS 61_ FADTI 66_ KVFQT 71_ ESHMK 76_ IVRKS 81_ EMEGC 86_ SAMVP 91_ SQLQL 96_ LPPGF 101_ KRFSC 106_ LSLPE 111_ TETGE 116_ NLLLI 121_ QNKKL 126_ EDNYC 131_ EITGM 136_ NTLLS 141_ APIHT 146_ QMQQK 151_ EFSII 156_ EHTRE 161_ RKHAN 166_ DQTVI 171_ FSDEN 176_ QMDLT 181_ SSHTV 186_ MITKG 191_ LLDNP 196_ ISEKS 201_ TKIDT 206_ TSFLA 211_ NLKLH 216_ TEDSR 221_ MKKEV 226_ NFSVD 231_ QNTSS 236_ ENKID 241_ FNDFI 246_ KRLKT 251_ GKCSA 256_ FPDVP 261_ DKENF 266_ EIPIY 271_ SKEPN 276_ SASST 281_ HQMHV 286_ SLKED 291_ ENNSN 296_ ITRLF 301_ REKDD 306_ GMNFT 311_ QCHTA 316_ NIQTL 321_ IPTSS 326_ ETNSR 331_ ESKGN 336_ DITIY 341_ GNDFM 346_ DLTFN 351_ HTLQI 356_ LPATG 361_ NFSEI 366_ ENQTQ 371_ NAMDV 376_ TTGYG 381_ TKASG 386_ NKTVF 391_ KSKQN 396_ TAFQD 401_ LSINS 406_ ADKIH 411_ ITRSH 416_ IMGAE 421_ THIVS 426_ QTCNQ 431_ DARIL 436_ AMTPE 441_ SIYSN 446_ PSIQG 451_ CKTVF 456_ YSSCN 461_ DAMEM 466_ TKCLS 471_ NMREE 476_ KNLLK 481_ HDSNY 486_ AKMYC 491_ NPDAM 496_ SSLTE 501_ KTIYS 506_ GEENM 511_ DITKS 516_ HTVAI 521_ DNQIF 526_ KQDQS 531_ NVQIA 536_ AAPTP 541_ EKEMM 546_ LQNLM 551_ TTSED 556_ GKMNV 561_ NCNSV 566_ PHVSK 571_ ERIQQ 576_ SLSNP 581_ LSISL 586_ TDRKT 591_ ELLSG 596_ ENMDL 601_ TESHT 606_ SNLGS 611_ QVPLA 616_ AYNLA 621_ PESTS 626_ ESHSQ 631_ SKSSS 636_ DECEE 641_ ITKSR 646_ NEPFQ 651_ RSDII 656_ AKNSL 661_ TDTWN 666_ KDKDW 671_ VLKIL 676_ PYLDK 681_ DSPQS 686_ ADCNQ 691_ EIATS 696_ HNIVY 701_ CGGVL 706_ DKQIT 711_ NRNTV 716_ SWEQS 721_ LFSTT 726_ KPLFS 731_ SGQFS 736_ MKNHD 741_ TAISS 746_ HTVKS 751_ VLGQN 756_ SKLAE 761_ PLRKS 766_ LSNPT 771_ PDYCH 776_ DKMII 781_ CSEEE 786_ QNMDL 791_ TKSHT 796_ VVIGF 801_ GPSEL 806_ QELGK 811_ TNLEH 816_ TTGQL 821_ TTMNR 826_ QIAVK 831_ VEKCG 836_ KSPIE 841_ KSGVL 846_ KSNCI 851_ MDVLE 856_ DESVQ 861_ KPKFP 866_ KEKQN 871_ VKIWG 876_ RKSVG 881_ GPKID 886_ KTIVF 891_ SEDDK 896_ NDMDI 901_ TKSYT 906_ IEINH 911_ RPLLE 916_ KRDCH 921_ LVPLA 926_ GTSET 931_ ILYTC 936_ RQDDM 941_ EITRS 946_ HTTAL 951_ ECKTV 956_ SPDEI 961_ TTRPM 966_ DKTVV 971_ FVDNH 976_ VELEM 981_ TESHT 986_ VFIDY 991_ QEKER 996_ TDRPN 1001_ FELSQ 1006_ RKSLG 1011_ TPTVI 1016_ CTPTE 1021_ ESVFF 1026_ PGNGE 1031_ SDRLV 1036_ ANDSQ 1041_ LTPLE 1046_ EWSNN 1051_ RGPVE 1056_ VADNM 1061_ ELSKS 1066_ ATCKN 1071_ IKDVQ 1076_ SPGFL 1081_ NEPLS 1086_ SKSQR 1091_ RKSLK 1096_ LKNDK 1101_ TIVFS 1106_ ENHKN 1111_ DMDIT 1116_ QSCMV 1121_ EIDNE 1126_ SALED 1131_ KEDFH 1136_ LAGAS 1141_ KTILY 1146_ SCGQD 1151_ DMEIT 1156_ RSHTT 1161_ ALECK 1166_ TLLPN 1171_ EIAIR 1176_ PMDKT 1181_ VLFTD 1186_ NYSDL 1191_ EVTDS 1196_ HTVFI 1201_ DCQAT 1206_ EKILE 1211_ ENPKF 1216_ GIGKG 1221_ KNLGV 1226_ SFPKD 1231_ NSCVQ 1236_ EIAEK 1241_ QALAV 1246_ GNKIV 1251_ LHTEQ 1256_ KQQLF 1261_ AATNR 1266_ TTNEI 1271_ IKFHS 1276_ AAMDE 1281_ KVIGK 1286_ VVDQA 1291_ CTLEK 1296_ AQVES 1301_ CQLNN 1306_ RDRRN 1311_ VDFTS 1316_ SHATA 1321_ VCGSS 1326_ DNYSC 1331_ LPNVI 1336_ SCTDN 1341_ LEGSA 1346_ MLLCD 1351_ KDEEK 1356_ ANYCP 1361_ VQNDL 1366_ AYAND 1371_ FASEY 1376_ YLESE 1381_ GQPLS 1386_ APCPL 1391_ LEKEE 1396_ VIQTS 1401_ TKGQL 1406_ DCVIT 1411_ LHKDQ 1416_ DLIKD 1421_ PRNLL 1426_ ANQTL 1431_ VYSQD 1436_ LGEMT 1441_ KLNSK 1446_ RVSFK 1451_ LPKDQ 1456_ MKVYV 1461_ DDIYV 1466_ IPQPH 1471_ FSTDQ 1476_ PPLPK 1481_ KGQSS 1486_ INKEE 1491_ VILSK 1496_ AGNKS 1501_ LNIIE 1506_ NSSAP 1511_ ICENK 1516_ PKILN 1521_ SEEWF 1526_ AAACK 1531_ KELKE 1536_ NIQTT 1541_ NYNTA 1546_ LDFHS 1551_ NSDVT 1556_ KQVIQ 1561_ THVNA 1566_ GEAPD 1571_ PVITS 1576_ NVPCF 1581_ HSIKP 1586_ NLNNL 1591_ NGKTG 1596_ EFLAF 1601_ QTVHL 1606_ PPLPE 1611_ QLLEL 1616_ GNKAH 1621_ NDMHI 1626_ VQATE 1631_ IHNIN 1636_ IISSN 1641_ AKDSR 1646_ DEENK 1651_ KSHNG 1656_ AETTS 1661_ LPPKT 1666_ VFKDK 1671_ VRRCS 1676_ LGIFL 1681_ PRLPN 1686_ KRNCS 1691_ VTGID 1696_ DLEQI 1701_ PADTT 1706_ DINHL 1711_ ETQPV 1716_ SSKDS 1721_ GIGSV 1726_ AGKLN 1731_ LSPSQ 1736_ YINEE 1741_ NLPVY 1746_ PDEIN 1751_ SSDSI 1756_ NIETE 1761_ EKALI 1766_ ETYQK 1771_ EISPY 1776_ ENKMG 1781_ KTCNS 1786_ QKRTW 1791_ VQEEE 1796_ DIHKE 1801_ KKIRK 1806_ NEIKF 1811_ SDTTQ 1816_ DREIF 1821_ DHHTE 1826_ EDIDK 1831_ SANSV 1836_ LIKNL 1841_ SRTPS 1846_ SCSSS 1851_ LDSIK 1856_ ADGTS 1861_ LDFST 1866_ YRSSQ 1871_ MESQF 1876_ LRDTI 1881_ CEESL 1886_ REKLQ 1891_ DGRIT 1896_ IREFF 1901_ ILLQV 1906_ HILIQ 1911_ KPRQS 1916_ NLPGN 1921_ FTVNT 1926_ PPTPE 1931_ DLMLS 1936_ QYVYR 1941_ PKIQI 1946_ YREDC 1951_ EARRQ 1956_ KIEEL 1961_ KLSAS 1966_ NQDKL 1971_ LVDIN 1976_ KNLWE 1981_ KMRHC 1986_ SDKEL 1991_ KAFGI 1996_ YLNKI 2001_ KSCFT 2006_ KMTKV 2011_ FTHQG 2016_ KVALY 2021_ GKLVQ 2026_ SAQNE 2031_ REKLQ 2036_ IKIDE 2041_ MDKIL 2046_ KKIDN 2051_ CLTEM 2056_ ETETK 2061_ NLEDE 2066_ EKNNP 2071_ VEEWD 2076_ SEMRA 2081_ AEKEL 2086_ EQLKT 2091_ EEEEL 2096_ QRNLL 2101_ ELEVQ 2106_ KEQTL 2111_ AQIDF 2116_ MQKQR 2121_ NRTEE 2126_ LLDQL 2131_ SLSEW 2136_ DVVEW 2141_ SDDQA 2146_ VFTFV 2151_ YDTIQ 2156_ LTITF 2161_ EESVV 2166_ GFPFL 2171_ DKRYR 2176_ KIVDV 2181_ NFQSL 2186_ LDEDQ 2191_ APPSS 2196_ LLVHK 2201_ LIFQY 2206_ VEEKE 2211_ SWKKT 2216_ CTTQH 2221_ QLPKM 2226_ LEEFS 2231_ LVVHH 2236_ CRLLG 2241_ EEIEY 2246_ LKRWG 2251_ PNYNL 2256_ MNIDI 2261_ NNNEL 2266_ RLLFS 2271_ SSAAF 2276_ AKFEI 2281_ TLFLS 2286_ AYYPS 2291_ VPLPS 2296_ TIQNH 2301_ VGNTS 2306_ QDDIA 2311_ TILSK 2316_ VPLEN 2321_ NYLKN 2326_ VVKQI 2331_ YQDLF 2336_QDCHF
1: Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions (PubMed:15502821, PubMed:17981135, PubMed:18045986, PubMed:19893618, PubMed:21199919, PubMed:22000412, PubMed:22331848, PubMed:27881301, PubMed:30100357). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (PubMed:18045986, PubMed:19893618, PubMed:27881301). The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:38459127, PubMed:38459128). Required for kinetochore binding by a distinct subset of kMAPs (kinetochore-bound microtubule-associated proteins) and motors (PubMed:19893618). Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore (PubMed:18045986, PubMed:27881301). Can bind either to microtubules or to the protein phosphatase 1 (PP1) catalytic subunits PPP1CA and PPP1CC (via overlapping binding sites), it has higher affinity for PP1 (PubMed:30100357). Recruits MAD2L1 to the kinetochore and also directly links BUB1 and BUB1B to the kinetochore (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:22331848, PubMed:25308863). In addition to orienting mitotic chromosomes, it is also essential for alignment of homologous chromosomes during meiotic metaphase I (By similarity). In meiosis I, required to activate the spindle assembly checkpoint at unattached kinetochores to correct erroneous kinetochore-microtubule attachments (By similarity)