Gene name: SVIP

Uniprot entry:

Q8NHG7

Protein names:

Small VCP/p97-interacting protein

Protein sequence:

1_MGLCF 6_ PCPGE 11_ SAPPT 16_ PDLEE 21_ KRAKL 26_ AEAAE 31_ RRQKE 36_ AASRG 41_ ILDVQ 46_ SVQEK 51_ RKKKE 56_ KIEKQ 61_ IATSG 66_ PPPEG 71_GLRWT

Protein annotations

Protein functions:

1: Negative regulator of the ER-associated degradation pathway (ERAD) of misfolded proteins. It competes with AMFR/gp78 for binding VCP/p97, and inhibits AMFR/gp78-VCP/p97 complex formation that is required for degradation of ERAD substrates (PubMed:17872946). Involved in the regulation of adrenal cortisol and dehydroepiandrosterone (DHEA) biosynthesis (PubMed:35042898)