E3 ubiquitin-protein ligase ZNRF2 (EC 2.3.2.27) (Protein Ells2) (RING finger protein 202) (RING-type E3 ubiquitin transferase ZNRF2) (Zinc/RING finger protein 2)
1_MGAKQ 6_ SGPAA 11_ ANGRT 16_ RAYSG 21_ SDLPS 26_ SSSGG 31_ ANGTA 36_ GGGGG 41_ ARAAA 46_ AGRFP 51_ AQVPS 56_ AHQPS 61_ ASGGA 66_ AAAAA 71_ APAAP 76_ AAPRS 81_ RSLGG 86_ AVGSV 91_ ASGAR 96_ AAQSP 101_ FSIPN 106_ SSSGP 111_ YGSQD 116_ SVHSS 121_ PEDGG 126_ GGRDR 131_ PVGGS 136_ PGGPR 141_ LVIGS 146_ LPAHL 151_ SPHMF 156_ GGFKC 161_ PVCSK 166_ FVSSD 171_ EMDLH 176_ LVMCL 181_ TKPRI 186_ TYNED 191_ VLSKD 196_ AGECA 201_ ICLEE 206_ LQQGD 211_ TIARL 216_ PCLCI 221_ YHKGC 226_ IDEWF 231_ EVNRS 236_CPEHP
1: E3 ubiquitin-protein ligase that plays a role in the establishment and maintenance of neuronal transmission and plasticity. Ubiquitinates the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1 and thereby influences its endocytosis and/or degradation (PubMed:22797923). Acts also as a positive regulator of mTORC1 activation by amino acids, which functions upstream of the V-ATPase and of Rag-GTPases (PubMed:27244671). In turn, phosphorylation by mTOR leads to its inhibition via targeting to the cytosol allowing a self-regulating feedback mechanism (PubMed:27244671)