Tubulin polyglutamylase TTLL11 (EC 6.3.2.-) (Tubulin--tyrosine ligase-like protein 11)
1_MAAAA 6_ SVTGR 11_ VTWAA 16_ SPMRS 21_ LGLGR 26_ RLSLP 31_ GPRLD 36_ AVTAA 41_ VNPSL 46_ SDHGN 51_ GLGRG 56_ TRGSG 61_ CSGGS 66_ LVADW 71_ GGGAA 76_ AAAAV 81_ ALALA 86_ PALST 91_ MRRGS 96_ SESEL 101_ AARWE 106_ AEAVA 111_ AAKAA 116_ AKAEA 121_ EATAE 126_ TVAEQ 131_ VRVDA 136_ GAAGE 141_ PECKA 146_ GEEQP 151_ KVLAP 156_ APAQP 161_ SAAEE 166_ GNTQV 171_ LQRPP 176_ PTLPP 181_ SKPKP 186_ VQGLC 191_ PHGKP 196_ RDKGR 201_ SCKRS 206_ SGHGS 211_ GENGS 216_ QRPVT 221_ VDSSK 226_ ARTSL 231_ DALKI 236_ SIRQL 241_ KWKEF 246_ PFGRR 251_ LPCDI 256_ YWHGV 261_ SFHDN 266_ DIFSG 271_ QVNKF 276_ PGMTE 281_ MVRKI 286_ TLSRA 291_ VRTMQ 296_ NLFPE 301_ EYNFY 306_ PRSWI 311_ LPDEF 316_ QLFVA 321_ QVQMV 326_ KDDDP 331_ SWKPT 336_ FIVKP 341_ DGGCQ 346_ GDGIY 351_ LIKDP 356_ SDIRL 361_ AGTLQ 366_ SRPAV 371_ VQEYI 376_ CKPLL 381_ IDKLK 386_ FDIRL 391_ YVLLK 396_ SLDPL 401_ EIYIA 406_ KDGLS 411_ RFCTE 416_ PYQEP 421_ TPKNL 426_ HRIFM 431_ HLTNY 436_ SLNIH 441_ SGNFI 446_ HSDSA 451_ STGSK 456_ RTFSS 461_ ILCRL 466_ SSKGV 471_ DIKKV 476_ WSDII 481_ SVVIK 486_ TVIAL 491_ TPELK 496_ VFYQS 501_ DIPTG 506_ RPGPT 511_ CFQIL 516_ GFDIL 521_ LMKNL 526_ KPILL 531_ EVNAN 536_ PSMRI 541_ EHEHE 546_ LSPGV 551_ FENVP 556_ SLVDE 561_ EVKVA 566_ VIRDT 571_ LRLMD 576_ PLKKK 581_ RENQS 586_ QQLEK 591_ PFAGK 596_ EDALD 601_ GELTS 606_ APDCN 611_ ANPEA 616_ HLPSI 621_ CLKQV 626_ FPKYA 631_ KQFNY 636_ LRLVD 641_ RMANL 646_ FIRFL 651_ GIKGT 656_ MKLGP 661_ TGFRT 666_ FIRSC 671_ KLSSS 676_ SLSMA 681_ AVDIL 686_ YIDIT 691_ RRWNS 696_ MTLDQ 701_ RDSGM 706_ CLQAF 711_ VEAFF 716_ FLAQR 721_ KFKML 726_ PLHEQ 731_ VASLI 736_ DLCEY 741_ HLSLL 746_ DEKRL 751_ VCGRG 756_ VPSGG 761_ RPPHR 766_ GPPQE 771_ PSPSA 776_ QPAGD 781_ NPPPR 786_ TSCAN 791_KLSHP
1: Polyglutamylase which modifies tubulin, generating polyglutamate side chains of variable lengths on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin. Preferentially mediates ATP-dependent polyglutamate long side-chain elongation over the initiation step of the polyglutamylation reaction. Preferentially modifies the alpha-tubulin tail over a beta-tail (By similarity). Required for CCSAP localization to both spindle and cilia microtubules (PubMed:22493317). Promotes tubulin polyglutamylation which stimulates spastin/SPAST-mediated microtubule severing, thereby regulating microtubule functions (By similarity)