Atlastin-2 (EC 3.6.5.-) (ADP-ribosylation factor-like protein 6-interacting protein 2) (ARL-6-interacting protein 2) (Aip-2)
1_MAEGD 6_ EAARG 11_ QQPHQ 16_ GLWRR 21_ RRTSD 26_ PSAAV 31_ NHVSS 36_ TTSLG 41_ ENYED 46_ DDLVN 51_ SDEVM 56_ KKPCP 61_ VQIVL 66_ AHEDD 71_ HNFEL 76_ DEEAL 81_ EQILL 86_ QEHIR 91_ DLNIV 96_ VVSVA 101_ GAFRK 106_ GKSFL 111_ LDFML 116_ RYMYN 121_ KDSQS 126_ WIGGN 131_ NEPLT 136_ GFTWR 141_ GGCER 146_ ETTGI 151_ QVWNE 156_ VFVID 161_ RPNGT 166_ KVAVL 171_ LMDTQ 176_ GAFDS 181_ QSTIK 186_ DCATV 191_ FALST 196_ MTSSV 201_ QVYNL 206_ SQNIQ 211_ EDDLQ 216_ HLQLF 221_ TEYGR 226_ LAMEE 231_ IYQKP 236_ FQTLM 241_ FLIRD 246_ WSYPY 251_ EHSYG 256_ LEGGK 261_ QFLEK 266_ RLQVK 271_ QNQHE 276_ ELQNV 281_ RKHIH 286_ NCFSN 291_ LGCFL 296_ LPHPG 301_ LKVAT 306_ NPSFD 311_ GRLKD 316_ IDEDF 321_ KRELR 326_ NLVPL 331_ LLAPE 336_ NLVEK 341_ EISGS 346_ KVTCR 351_ DLVEY 356_ FKAYI 361_ KIYQG 366_ EELPH 371_ PKSML 376_ QATAE 381_ ANNLA 386_ AVAGA 391_ RDTYC 396_ KSMEQ 401_ VCGGD 406_ KPYIA 411_ PSDLE 416_ RKHLD 421_ LKEVA 426_ IKQFR 431_ SVKKM 436_ GGDEF 441_ CRRYQ 446_ DQLEA 451_ EIEET 456_ YANFI 461_ KHNDG 466_ KNIFY 471_ AARTP 476_ ATLFA 481_ VMFAM 486_ YIISG 491_ LTGFI 496_ GLNSI 501_ AVLCN 506_ LVMGL 511_ ALIFL 516_ CTWAY 521_ VKYSG 526_ EFREI 531_ GTVID 536_ QIAET 541_ LWEQV 546_ LKPLG 551_ DNLME 556_ ENIRQ 561_ SVTNS 566_ IKAGL 571_ TDQVS 576_HHARL
1: Atlastin-2 (ATL2) is a membrane-anchored GTPase that mediates the GTP-dependent fusion of endoplasmic reticulum (ER) membranes, maintaining the continuous ER network. It facilitates the formation of three-way junctions where ER tubules intersect (PubMed:18270207, PubMed:19665976, PubMed:22065636, PubMed:27619977, PubMed:34817557). Two atlastin-2 on neighboring ER tubules bind GTP and form loose homodimers through the GB1/RHD3-type G domains and 3HB regions. Upon GTP hydrolysis, the 3HB regions tighten, pulling the membranes together to drive their fusion. After fusion, the homodimer disassembles upon release of inorganic phosphate (Pi). Subsequently, GDP dissociates, resetting the monomers to a conformation ready for a new fusion cycle (By similarity)