Leukocyte immunoglobulin-like receptor subfamily B member 4 (B4) (CD85 antigen-like family member K) (Immunoglobulin-like transcript 3) (ILT-3) (Leukocyte immunoglobulin-like receptor 5) (LIR-5) (Monocyte inhibitory receptor HM18) (CD antigen CD85k)
1_MIPTF 6_ TALLC 11_ LGLSL 16_ GPRTH 21_ MQAGP 26_ LPKPT 31_ LWAEP 36_ GSVIS 41_ WGNSV 46_ TIWCQ 51_ GTLEA 56_ REYRL 61_ DKEES 66_ PAPWD 71_ RQNPL 76_ EPKNK 81_ ARFSI 86_ PSMTE 91_ DYAGR 96_ YRCYY 101_ RSPVG 106_ WSQPS 111_ DPLEL 116_ VMTGA 121_ YSKPT 126_ LSALP 131_ SPLVT 136_ SGKSV 141_ TLLCQ 146_ SRSPM 151_ DTFLL 156_ IKERA 161_ AHPLL 166_ HLRSE 171_ HGAQQ 176_ HQAEF 181_ PMSPV 186_ TSVHG 191_ GTYRC 196_ FSSHG 201_ FSHYL 206_ LSHPS 211_ DPLEL 216_ IVSGS 221_ LEDPR 226_ PSPTR 231_ SVSTA 236_ AGPED 241_ QPLMP 246_ TGSVP 251_ HSGLR 256_ RHWEV 261_ LIGVL 266_ VVSIL 271_ LLSLL 276_ LFLLL 281_ QHWRQ 286_ GKHRT 291_ LAQRQ 296_ ADFQR 301_ PPGAA 306_ EPEPK 311_ DGGLQ 316_ RRSSP 321_ AADVQ 326_ GENFC 331_ AAVKN 336_ TQPED 341_ GVEMD 346_ TRQSP 351_ HDEDP 356_ QAVTY 361_ AKVKH 366_ SRPRR 371_ EMASP 376_ PSPLS 381_ GEFLD 386_ TKDRQ 391_ AEEDR 396_ QMDTE 401_ AAASE 406_ APQDV 411_ TYAQL 416_ HSFTL 421_ RQKAT 426_ EPPPS 431_ QEGAS 436_ PAEPS 441_VYATL
1: Inhibitory receptor involved in the down-regulation of the immune response and the development of immune tolerance (PubMed:11875462). Receptor for FN1 (PubMed:34089617). Receptor for apolipoprotein APOE (PubMed:30333625). Receptor for ALCAM/CD166 (PubMed:29263213). Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:9151699). Inhibits FCGR1A/CD64-mediated monocyte activation by inducing phosphatase-mediated down-regulation of the phosphorylation of multiple proteins including LCK, SYK, LAT and ERK, leading to a reduction in TNF production (PubMed:19833736). This inhibition of monocyte activation occurs at least in part via binding to FN1 (PubMed:34089617). Inhibits T cell proliferation, inducing anergy, suppressing the differentiation of IFNG-producing CD8+ cytotoxic T cells and enhancing the generation of CD8+ T suppressor cells (PubMed:16493035, PubMed:19833736, PubMed:29263213). Induces up-regulation of CD86 on dendritic cells (PubMed:19860908). Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation (PubMed:11875462)