Leukocyte immunoglobulin-like receptor subfamily B member 1 (LIR-1) (Leukocyte immunoglobulin-like receptor 1) (CD85 antigen-like family member J) (Immunoglobulin-like transcript 2) (ILT-2) (Monocyte/macrophage immunoglobulin-like receptor 7) (MIR-7) (CD antigen CD85j)
1_MTPIL 6_ TVLIC 11_ LGLSL 16_ GPRTH 21_ VQAGH 26_ LPKPT 31_ LWAEP 36_ GSVIT 41_ QGSPV 46_ TLRCQ 51_ GGQET 56_ QEYRL 61_ YREKK 66_ TALWI 71_ TRIPQ 76_ ELVKK 81_ GQFPI 86_ PSITW 91_ EHAGR 96_ YRCYY 101_ GSDTA 106_ GRSES 111_ SDPLE 116_ LVVTG 121_ AYIKP 126_ TLSAQ 131_ PSPVV 136_ NSGGN 141_ VILQC 146_ DSQVA 151_ FDGFS 156_ LCKEG 161_ EDEHP 166_ QCLNS 171_ QPHAR 176_ GSSRA 181_ IFSVG 186_ PVSPS 191_ RRWWY 196_ RCYAY 201_ DSNSP 206_ YEWSL 211_ PSDLL 216_ ELLVL 221_ GVSKK 226_ PSLSV 231_ QPGPI 236_ VAPEE 241_ TLTLQ 246_ CGSDA 251_ GYNRF 256_ VLYKD 261_ GERDF 266_ LQLAG 271_ AQPQA 276_ GLSQA 281_ NFTLG 286_ PVSRS 291_ YGGQY 296_ RCYGA 301_ HNLSS 306_ EWSAP 311_ SDPLD 316_ ILIAG 321_ QFYDR 326_ VSLSV 331_ QPGPT 336_ VASGE 341_ NVTLL 346_ CQSQG 351_ WMQTF 356_ LLTKE 361_ GAADD 366_ PWRLR 371_ STYQS 376_ QKYQA 381_ EFPMG 386_ PVTSA 391_ HAGTY 396_ RCYGS 401_ QSSKP 406_ YLLTH 411_ PSDPL 416_ ELVVS 421_ GPSGG 426_ PSSPT 431_ TGPTS 436_ TSGPE 441_ DQPLT 446_ PTGSD 451_ PQSGL 456_ GRHLG 461_ VVIGI 466_ LVAVI 471_ LLLLL 476_ LLLLF 481_ LILRH 486_ RRQGK 491_ HWTST 496_ QRKAD 501_ FQHPA 506_ GAVGP 511_ EPTDR 516_ GLQWR 521_ SSPAA 526_ DAQEE 531_ NLYAA 536_ VKHTQ 541_ PEDGV 546_ EMDTR 551_ SPHDE 556_ DPQAV 561_ TYAEV 566_ KHSRP 571_ RREMA 576_ SPPSP 581_ LSGEF 586_ LDTKD 591_ RQAEE 596_ DRQMD 601_ TEAAA 606_ SEAPQ 611_ DVTYA 616_ QLHSL 621_ TLRRE 626_ ATEPP 631_ PSQEG 636_ PSPAV 641_PSIYA
1: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles (PubMed:16455647, PubMed:28636952). Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of FCER1A signaling and serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:11907092, PubMed:9285411, PubMed:9842885). Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (PubMed:16455647). Upon interaction with peptide-bound HLA-G-B2M complex, triggers secretion of growth-promoting factors by decidual NK cells (PubMed:19304799, PubMed:29262349). Reprograms B cells toward an immune suppressive phenotype (PubMed:24453251)