Lysine-specific demethylase 2B (EC 1.14.11.27) (CXXC-type zinc finger protein 2) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) (Jumonji domain-containing EMSY-interactor methyltransferase motif protein) (Protein JEMMA) (Protein-containing CXXC domain 2) ([Histone-H3]-lysine-36 demethylase 1B)
1_MAGPQ 6_ MGGSA 11_ EDHPP 16_ RKRHA 21_ AEKQK 26_ KKTVI 31_ YTKCF 36_ EFESA 41_ TQRPI 46_ DRQRY 51_ DENED 56_ LSDVE 61_ EIVSV 66_ RGFSL 71_ EEKLR 76_ SQLYQ 81_ GDFVH 86_ AMEGK 91_ DFNYE 96_ YVQRE 101_ ALRVP 106_ LIFRE 111_ KDGLG 116_ IKMPD 121_ PDFTV 126_ RDVKL 131_ LVGSR 136_ RLVDV 141_ MDVNT 146_ QKGTE 151_ MSMSQ 156_ FVRYY 161_ ETPEA 166_ QRDKL 171_ YNVIS 176_ LEFSH 181_ TKLEH 186_ LVKRP 191_ TVVDL 196_ VDWVD 201_ NMWPQ 206_ HLKEK 211_ QTEAT 216_ NAIAE 221_ MKYPK 226_ VKKYC 231_ LMSVK 236_ GCFTD 241_ FHIDF 246_ GGTSV 251_ WYHVF 256_ RGGKI 261_ FWLIP 266_ PTLHN 271_ LALYE 276_ EWVLS 281_ GKQSD 286_ IFLGD 291_ RVERC 296_ QRIEL 301_ KQGYT 306_ FFIPS 311_ GWIHA 316_ VYTPV 321_ DSLVF 326_ GGNIL 331_ HSFNV 336_ PMQLR 341_ IYEIE 346_ DRTRV 351_ QPKFR 356_ YPFYY 361_ EMCWY 366_ VLERY 371_ VYCVT 376_ QRSHL 381_ TQEYQ 386_ RESML 391_ IDAPR 396_ KPSID 401_ GFSSD 406_ SWLEM 411_ EEEAC 416_ DQQPQ 421_ EEEEK 426_ DEEGE 431_ GRDRA 436_ PKPPT 441_ DGSTS 446_ PTSTP 451_ SEDQE 456_ ALGKK 461_ PKAPA 466_ LRFLK 471_ RTLSN 476_ ESEES 481_ VKSTT 486_ LAVDY 491_ PKTPT 496_ GSPAT 501_ EVSAK 506_ WTHLT 511_ EFELK 516_ GLKAL 521_ VEKLE 526_ SLPEN 531_ KKCVP 536_ EGIED 541_ PQALL 546_ EGVKN 551_ VLKEH 556_ ADDDP 561_ SLAIT 566_ GVPVV 571_ TWPKK 576_ TPKNR 581_ AVGRP 586_ KGKLG 591_ PASAV 596_ KLAAN 601_ RTTAG 606_ ARRRR 611_ TRCRK 616_ CEACL 621_ RTECG 626_ ECHFC 631_ KDMKK 636_ FGGPG 641_ RMKQS 646_ CIMRQ 651_ CIAPV 656_ LPHTA 661_ VCLVC 666_ GEAGK 671_ EDTVE 676_ EEEGK 681_ FNLML 686_ MECSI 691_ CNEII 696_ HPGCL 701_ KIKES 706_ EGVVN 711_ DELPN 716_ CWECP 721_ KCNHA 726_ GKTGK 731_ QKRGP 736_ GFKYA 741_ SNLPG 746_ SLLKE 751_ QKMNR 756_ DNKEG 761_ QEPAK 766_ RRSEC 771_ EEAPR 776_ RRSDE 781_ HSKKV 786_ PPDGL 791_ LRRKS 796_ DDVHL 801_ RKKRK 806_ YEKPQ 811_ ELSGR 816_ KRASS 821_ LQTSP 826_ GSSSH 831_ LSPRP 836_ PLGSS 841_ LSPWW 846_ RSSLT 851_ YFQQQ 856_ LKPGK 861_ EDKLF 866_ RKKRR 871_ SWKNA 876_ EDRMA 881_ LANKP 886_ LRRFK 891_ QEPED 896_ ELPEA 901_ PPKTR 906_ ESDHS 911_ RSSSP 916_ TAGPS 921_ TEGAE 926_ GPEEK 931_ KKVKM 936_ RRKRR 941_ LPNKE 946_ LSREL 951_ SKELN 956_ HEIQR 961_ TENSL 966_ ANENQ 971_ QPIKS 976_ EPESE 981_ GEEPK 986_ RPPGI 991_ CERPH 996_ RFSKG 1001_ LNGTP 1006_ RELRH 1011_ QLGPS 1016_ LRSPP 1021_ RVISR 1026_ PPPSV 1031_ SPPKC 1036_ IQMER 1041_ HVIRP 1046_ PPISP 1051_ PPDSL 1056_ PLDDG 1061_ AAHVM 1066_ HREVW 1071_ MAVFS 1076_ YLSHQ 1081_ DLCVC 1086_ MRVCR 1091_ TWNRW 1096_ CCDKR 1101_ LWTRI 1106_ DLNHC 1111_ KSITP 1116_ LMLSG 1121_ IIRRQ 1126_ PVSLD 1131_ LSWTN 1136_ ISKKQ 1141_ LSWLI 1146_ NRLPG 1151_ LRDLV 1156_ LSGCS 1161_ WIAVS 1166_ ALCSS 1171_ SCPLL 1176_ RTLDV 1181_ QWVEG 1186_ LKDAQ 1191_ MRDLL 1196_ SPPTD 1201_ NRPGQ 1206_ MDNRS 1211_ KLRNI 1216_ VELRL 1221_ AGLDI 1226_ TDASL 1231_ RLIIR 1236_ HMPLL 1241_ SKLHL 1246_ SYCNH 1251_ VTDQS 1256_ INLLT 1261_ AVGTT 1266_ TRDSL 1271_ TEINL 1276_ SDCNK 1281_ VTDQC 1286_ LSFFK 1291_ RCGNI 1296_ CHIDL 1301_ RYCKQ 1306_ VTKEG 1311_ CEQFI 1316_ AEMSV 1321_ SVQFG 1326_ QVEEK 1331_LLQKL
1: Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36' (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation (PubMed:16362057, PubMed:17994099). May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable)