Motile sperm domain-containing protein 2
1_MAENH 6_ AQNKA 11_ KLISE 16_ TRRRF 21_ EAEYV 26_ TDKSD 31_ KYDAR 36_ DVERL 41_ QQDDN 46_ WVESY 51_ LSWRH 56_ NIVDE 61_ TLKML 66_ DESFQ 71_ WRKEI 76_ SVNDL 81_ NESSI 86_ PRWLL 91_ EIGVI 96_ YLHGY 101_ DKEGN 106_ KLFWI 111_ RVKYH 116_ VKDQK 121_ TILDK 126_ KKLIA 131_ FWLER 136_ YAKRE 141_ NGKPV 146_ TVMFD 151_ LSETG 156_ INSID 161_ MDFVR 166_ FIINC 171_ FKVYY 176_ PKYLS 181_ KIVIF 186_ DMPWL 191_ MNAAF 196_ KIVKT 201_ WLGPE 206_ AVSLL 211_ KFTSK 216_ NEVQD 221_ YVSVE 226_ YLPPH 231_ MGGTD 236_ PFKYS 241_ YPPLV 246_ DDDFQ 251_ TPLCE 256_ NGPIT 261_ SEDET 266_ SSKED 271_ IESDG 276_ KETLE 281_ TISNE 286_ EQTPL 291_ LKKIN 296_ PTEST 301_ SKAEE 306_ NEKVD 311_ SKVKA 316_ FKKPL 321_ SVFKG 326_ PLLHI 331_ SPAEE 336_ LYFGS 341_ TESGE 346_ KKTLI 351_ VLTNV 356_ TKNIV 361_ AFKVR 366_ TTAPE 371_ KYRVK 376_ PSNSS 381_ CDPGA 386_ SVDIV 391_ VSPHG 396_ GLTVS 401_ AQDRF 406_ LIMAA 411_ EMEQS 416_ SGTGP 421_ AELTQ 426_ FWKEV 431_ PRNKV 436_ MEHRL 441_ RCHTV 446_ ESSKP 451_ NTLTL 456_ KDNAF 461_ NMSDK 466_ TSEDI 471_ CLQLS 476_ RLLES 481_ NRKLE 486_ DQVQR 491_ CIWFQ 496_ QLLLS 501_ LTMLL 506_ LAFVT 511_SFFYL
1: Endoplasmic reticulum-anchored protein that mediates the formation of contact sites between the endoplasmic (ER) and endosomes, mitochondria or Golgi through interaction with conventional- and phosphorylated-FFAT-containing organelle-bound proteins (PubMed:29858488, PubMed:33124732, PubMed:35389430). In addition, forms endoplasmic reticulum (ER)-lipid droplets (LDs) contacts through a direct protein-membrane interaction and participates in LDs homeostasis (PubMed:35389430). The attachment mechanism involves an amphipathic helix that has an affinity for lipid packing defects present at the surface of LDs (PubMed:35389430). Promotes migration of primary monocytes and neutrophils, in response to various chemokines (PubMed:28137892)