piRNA biogenesis protein EXD1 (Exonuclease 3'-5' domain-containing protein 1) (Exonuclease 3'-5' domain-like-containing protein 1) (Inactive exonuclease EXD1)
1_MEDSE 6_ FLAYV 11_ ELLDE 16_ VEQGS 21_ VRAKA 26_ SSVSL 31_ HAERT 36_ WMEKM 41_ KVEDL 46_ NVCEP 51_ ASPAP 56_ EAPAT 61_ SLLND 66_ LKYSP 71_ SEEEE 76_ VTYTV 81_ INQFQ 86_ QKFGA 91_ AILHI 96_ KKQNV 101_ LSVAA 106_ EGANV 111_ CRHGK 116_ LCWLQ 121_ VATNC 126_ RVYLF 131_ DIFLL 136_ GSRAF 141_ HNGLQ 146_ MILED 151_ KRILK 156_ VIHDC 161_ RWLSD 166_ CLSHQ 171_ YGILL 176_ NNVFD 181_ TQVAD 186_ VLQFS 191_ METGG 196_ YLPNC 201_ ITTLQ 206_ ESLIK 211_ HLQVA 216_ PKYLS 221_ FLEKR 226_ QKLIQ 231_ ENPEV 236_ WFIRP 241_ VSPSL 246_ LKILA 251_ LEATY 256_ LLPLR 261_ LALLD 266_ EMMSD 271_ LTTLV 276_ DGYLN 281_ TYREG 286_ SADRL 291_ GGTEP 296_ TCMEL 301_ PEELL 306_ QLKDF 311_ QKQRR 316_ EKAAR 321_ EYRVN 326_ AQGLL 331_ IRTVL 336_ QPKKL 341_ VTETA 346_ GKEEK 351_ VKGFL 356_ FGKNF 361_ RIDKA 366_ PSFTS 371_ QDFHG 376_ DVNLL 381_ KEESL 386_ NKQAT 391_ NPQHL 396_ PPTEE 401_ GETSE 406_ DSSNK 411_ LICTK 416_ SKGSE 421_ DQRIT 426_ QKEHF 431_ MTPKH 436_ EFQAS 441_ LSLKE 446_ ETEQL 451_ LMVEN 456_ KEDLK 461_ CTKQA 466_ VSMSS 471_ FPQET 476_ RVSPS 481_ DTFYP 486_ IRKTV 491_ VSTLP 496_ PCPAL 501_ EKIDS 506_WISPF
1: RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity (By similarity). The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs. In the PET complex, EXD1 probably acts as an RNA adapter. EXD1 is an inactive exonuclease (By similarity)