Gene name: PFN4

Uniprot entry:

Q8NHR9

Protein names:

Profilin-4 (Profilin IV)

Protein sequence:

1_MSHLQ 6_ SLLLD 11_ TLLGT 16_ KHVDS 21_ AALIK 26_ IQERS 31_ LCVAS 36_ PGFNV 41_ TPSDV 46_ RTLVN 51_ GFAKN 56_ PLQAR 61_ REGLY 66_ FKGKD 71_ YRCVR 76_ ADEYS 81_ LYAKN 86_ ENTGV 91_ VVVKT 96_ HLYLL 101_ VATYT 106_ EGMYP 111_ SICVE 116_ ATESL 121_GDYLR

Protein annotations

Protein functions:

1: Involved in male fertility. Required for manchette development and acrosome biogenesis during spermiogenesis (By similarity). Binds in vitro to phospholipids, including phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidic acid (PA) (PubMed:19419568). Contrary to other profilin family members, does not bind to actin in vitro (PubMed:19419568)