Major facilitator superfamily domain-containing protein 8 (Ceroid-lipofuscinosis neuronal protein 7)
1_MAGLR 6_ NESEQ 11_ EPLLG 16_ DTPGS 21_ REWDI 26_ LETEE 31_ HYKSR 36_ WRSIR 41_ ILYLT 46_ MFLSS 51_ VGFSV 56_ VMMSI 61_ WPYLQ 66_ KIDPT 71_ ADTSF 76_ LGWVI 81_ ASYSL 86_ GQMVA 91_ SPIFG 96_ LWSNY 101_ RPRKE 106_ PLIVS 111_ ILISV 116_ AANCL 121_ YAYLH 126_ IPASH 131_ NKYYM 136_ LVARG 141_ LLGIG 146_ AGNVA 151_ VVRSY 156_ TAGAT 161_ SLQER 166_ TSSMA 171_ NISMC 176_ QALGF 181_ ILGPV 186_ FQTCF 191_ TFLGE 196_ KGVTW 201_ DVIKL 206_ QINMY 211_ TTPVL 216_ LSAFL 221_ GILNI 226_ ILILA 231_ ILREH 236_ RVDDS 241_ GRQCK 246_ SINFE 251_ EASTD 256_ EAQVP 261_ QGNID 266_ QVAVV 271_ AINVL 276_ FFVTL 281_ FIFAL 286_ FETII 291_ TPLTM 296_ DMYAW 301_ TQEQA 306_ VLYNG 311_ IILAA 316_ LGVEA 321_ VVIFL 326_ GVKLL 331_ SKKIG 336_ ERAIL 341_ LGGLI 346_ VVWVG 351_ FFILL 356_ PWGNQ 361_ FPKIQ 366_ WEDLH 371_ NNSIP 376_ NTTFG 381_ EIIIG 386_ LWKSP 391_ MEDDN 396_ ERPTG 401_ CSIEQ 406_ AWCLY 411_ TPVIH 416_ LAQFL 421_ TSAVL 426_ IGLGY 431_ PVCNL 436_ MSYTL 441_ YSKIL 446_ GPKPQ 451_ GVYMG 456_ WLTAS 461_ GSGAR 466_ ILGPM 471_ FISQV 476_ YAHWG 481_ PRWAF 486_ SLVCG 491_ IIVLT 496_ ITLLG 501_ VVYKR 506_ LIALS 511_VRYGR
1: Outward-rectifying chloride channel involved in endolysosomal chloride homeostasis, membrane fusion and function. Conducts chloride currents up to hundreds of picoamperes. Regulates lysosomal calcium content by reducing the lysosomal membrane potential, thereby activating TRPML1 channel and further release of lysosomal calcium ions. Regulates the pH in endolysosomal compartments and may contribute to progressive acidification from endosome to lysosome. Permeable to other halides such as iodide and fluoride ions