Gene name: MOSMO

Uniprot entry:

Q8NHV5

Protein names:

Modulator of smoothened protein (Attenuator of hedgehog)

Protein sequence:

1_MDKLT 6_ IISGC 11_ LFLAA 16_ DIFAI 21_ ASIAN 26_ PDWIN 31_ TGESA 36_ GALTV 41_ GLVRQ 46_ CQTIH 51_ GRDRT 56_ CIPPR 61_ LPPEW 66_ VTTLF 71_ FIIMG 76_ IISLT 81_ VTCGL 86_ LVASH 91_ WRREA 96_ TKYAR 101_ WIAFT 106_ GMILF 111_ CMAAL 116_ IFPIG 121_ FYINE 126_ VGGQP 131_ YKLPN 136_ NTVVG 141_ SSYVL 146_ FVLSI 151_ FFTIV 156_ GLLFA 161_GKVCL

Protein annotations

Protein functions:

1: Acts as a negative regulator of hedgehog signaling probably by promoting internalization and subsequent degradation of smoothened protein (SMO) present in the ciliary membrane. Plays a role in sonic hedgehog (SHH)-induced spinal neural progenitor cells differentiation