Transcription factor MafA (Pancreatic beta-cell-specific transcriptional activator) (RIPE3b1 factor) (V-maf musculoaponeurotic fibrosarcoma oncogene homolog A)
1_MAAEL 6_ AMGAE 11_ LPSSP 16_ LAIEY 21_ VNDFD 26_ LMKFE 31_ VKKEP 36_ PEAER 41_ FCHRL 46_ PPGSL 51_ SSTPL 56_ STPCS 61_ SVPSS 66_ PSFCA 71_ PSPGT 76_ GGGGG 81_ AGGGG 86_ GSSQA 91_ GGAPG 96_ PPSGG 101_ PGAVG 106_ GTSGK 111_ PALED 116_ LYWMS 121_ GYQHH 126_ LNPEA 131_ LNLTP 136_ EDAVE 141_ ALIGS 146_ GHHGA 151_ HHGAH 156_ HPAAA 161_ AAYEA 166_ FRGPG 171_ FAGGG 176_ GADDM 181_ GAGHH 186_ HGAHH 191_ AAHHH 196_ HAAHH 201_ HHHHH 206_ HHHGG 211_ AGHGG 216_ GAGHH 221_ VRLEE 226_ RFSDD 231_ QLVSM 236_ SVREL 241_ NRQLR 246_ GFSKE 251_ EVIRL 256_ KQKRR 261_ TLKNR 266_ GYAQS 271_ CRFKR 276_ VQQRH 281_ ILESE 286_ KCQLQ 291_ SQVEQ 296_ LKLEV 301_ GRLAK 306_ ERDLY 311_ KEKYE 316_ KLAGR 321_ GGPGS 326_ AGGAG 331_ FPREP 336_ SPPQA 341_ GPGGA 346_KGTAD
1: Transcription factor that activates insulin gene expression (PubMed:12011435, PubMed:15993959). Acts synergistically with NEUROD1/BETA2 and PDX1 (PubMed:15993959). Binds the insulin enhancer C1/RIPE3b element (PubMed:12011435). Binds to consensus TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequence (PubMed:23148532, PubMed:29339498)